Evidence map›Paper›PMID 36992483›Full record

ArticleViruses2023

Toll-like Receptor-Mediated Immunomodulation of Th1-Type Response Stimulated by Recombinant Antigen of Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2).

Rika Wahyuningtyas, Mei-Li Wu, Wen-Bin Chung, Hso-Chi Chaung, Ko-Tung Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rika WahyuningtyasResearch Centre for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.ORCID 0000-0002-4150-266X
Mei-Li WuResearch Centre for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Wen-Bin ChungResearch Centre for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.
Hso-Chi ChaungResearch Centre for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.ORCID 0000-0002-4354-9840
Ko-Tung ChangResearch Centre for Animal Biologics, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan.ORCID 0000-0001-9383-831X
National Pingtung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PRRSV infects CD163-positive macrophages and skews their polarization toward an M2 phenotype, followed by T-cell inactivation. In our previous study, we found that recombinant protein A1 antigen derived from PRRSV-2 was a potential vaccine or adjuvant for immunization against PRRSV-2 infection due to its ability to repolarize macrophages into M1 subtype, thereby reducing CD163 expression for viral entry and promoting immunomodulation for Th1-type responses, except for stimulating Toll-like receptor (TLR) activation. The aim of our current study was to evaluate the effects of another two recombinant antigens, A3 (ORF6L5) and A4 (NLNsp10L11), for their ability to trigger innate immune responses including TLR activation. We isolated pulmonary alveolar macrophages (PAMs) from 8- to 12-week-old specific pathogen free (SPF) piglets and stimulated them with PRRSV (0.01 MOI and 0.05 MOI) or antigens. We also investigated the T-cell differentiation by immunological synapse activation of PAMs and CD4

Indexed as

Porcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusAnimalsImmunity, InnateImmunomodulationInterleukin-12Recombinant ProteinsSwineToll-Like Receptor 3Toll-Like ReceptorsInterleukin-12Recombinant ProteinsToll-Like Receptor 3Toll-Like ReceptorsM1M2porcine alveolar macrophagesporcine reproductive and respiratory syndrome virusToll-like receptors

Identifiers

PMID36992483
PMCPMC10057405
OpenAlexW4327956733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.