Evidence map›Paper›PMID 36992467›Full record

ArticleViruses2023

Cervicovaginal Human Papillomavirus Genomes, Microbiota Composition and Cytokine Concentrations in South African Adolescents.

Anna-Ursula Happel, Christina Balle, Enock Havyarimana, Bryan Brown, Brandon S Maust, Colin Feng, Byung H Yi, Katherine Gill, Linda-Gail Bekker, Jo-Ann S Passmore and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Anna-Ursula HappelDepartment of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.ORCID 0000-0003-3658-8638
Christina BalleDepartment of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.ORCID 0000-0003-3439-3992
Enock HavyarimanaDepartment of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.ORCID 0000-0001-6185-8607
Bryan BrownSeattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.ORCID 0000-0002-4476-6150
Brandon S MaustSeattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.ORCID 0000-0002-3174-9036
Colin FengSeattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.
Byung H YiSeattle Children's Research Institute, 307 Westlake Ave. N, Seattle, WA 98109, USA.
Katherine GillDesmond Tutu Health Foundation, 3 Woodlands Rd, Woodstock, Cape Town 7915, South Africa.
Linda-Gail BekkerDesmond Tutu Health Foundation, 3 Woodlands Rd, Woodstock, Cape Town 7915, South Africa.
Jo-Ann S PassmoreDepartment of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Heather B JaspanDepartment of Pathology, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.
Arvind VarsaniThe Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine and School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-4111-2415
University of Cape Town · ZADesmond Tutu HIV Foundation · ZAUniversity of Washington · USNational Health Laboratory Service · ZA

Funding

ACADEMIC PEDIATRIC INFECTIOUS DISEASET32HD007233 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI KEVIN B URDAHL · 1985 to 2026
$6.7M
CHAMPS: Choices for Adolescent Methods of Prevention in South AfricaR01AI094586 · NIAID · DESMOND TUTU HIV FOUNDATION · PI BEKKER, LINDA-GAIL GAIL · 2011 to 2014
$2.5M
Hormone induced mucosal susceptibility and HIV risk in South African adolescentsR01HD083040 · NICHD · UNIVERSITY OF CAPE TOWN · PI JASPAN, HEATHER BERYL, PASSMORE, JO-ANN SHELLEY · 2015 to 2019
$1.9M
Gates Foundation INV-037612NIAID NIH HHS R01 AI094586NICHD NIH HHS R01 HD083040NICHD NIH HHS T32 HD007233NIH HHS R01 AI094586NIH HHS R01 HD083040-02S1
6 · The paper itself

Abstract

The interaction between cervicovaginal virome, bacteriome and genital inflammation has not been extensively investigated. We assessed the vaginal DNA virome from 33 South African adolescents (15-19 years old) using shotgun DNA sequencing of purified virions. We present analyses of eukaryote-infecting DNA viruses, with a focus on human papillomavirus (HPV) genomes and relate these to the vaginal bacterial microbiota (assessed by 16S rRNA gene sequencing) and cytokines (assessed by Luminex). The DNA virome included single-stranded (

Indexed as

HerpesviridaeMicrobiotaPapillomavirus InfectionsVaginosis, BacterialAdolescentAdultAlphapapillomavirusBacteriaCytokinesFemaleHuman Papillomavirus VirusesHumansInflammationPapillomaviridaeRNA, Ribosomal, 16SSouth AfricaCytokinesRNA, Ribosomal, 16SAlphapapillomavirusDNA virusesGammapapillomavirusgenital inflammationHPVmicrobiomeSub-Saharan Africavaginal viromewhole genomewomen’s health

Identifiers

PMID36992467
PMCPMC10054107
OpenAlexW4327621000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.