ArticleViruses2023
Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial Remodeling.
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Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
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31 citing papers in PubMed, 38 citations in OpenAlex.
- Blood-Brain Barrier Changes and Related Microvascular Outcomes in Long-COVID: A Comprehensive Review.Life (Basel, Switzerland) · 2026Review
- Mitochondrial control of blood-brain barrier homeostasis in neuroinflammatory psychiatric disorders.Frontiers in molecular neuroscience · 2026Review
- Transcriptomic profiling of endothelial progenitor cells in post-COVID-19 patients: Insights at 3 and 6-month post-infection.iScience · 2025Article
- Comprehensive mapping of the signaling events evoked by SARS-CoV-2 variants delta and omicron in human astrocytes.Scientific reports · 2025Article
- SARS-CoV-2 Infection Influences Wnt/β-Catenin Pathway Components in Astrocytes.Pathogens (Basel, Switzerland) · 2025Article
- SARS-Cov-2 Replication in a Blood-Brain Barrier Model Established with Human Brain Microvascular Endothelial Cells Induces Permeability and Disables ACE2-Dependent Regulation of Bradykinin B1 Receptor.International journal of molecular sciences · 2025Article
- Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation.Journal of neuroinflammation · 2025Review
- Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health.GeroScience · 2025Review
- Nucleotide metabolic abnormalities in post-COVID-19 condition and type 2 diabetes mellitus patients and their association with endocrine dysfunction.Open medicine (Warsaw, Poland) · 2025Article
- Distinct ZIKV strain signatures and type I IFN modulation reveal a protective role of brain endothelial interferon signalingFrontiers in cellular and infection microbiology · 2025Article
- COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment.Biomolecules · 2024Article
- Cerebral small vessel injury in mice with damage to ACE2-expressing cerebral vascular endothelial cells and post COVID-19 patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Is There such a Thing as Post-Viral Depression?: Implications for Precision Medicine.Biomolecules & therapeutics · 2024Review
- Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches.GeroScience · 2024Review
- Exploring the Complexities of Long COVID.Viruses · 2024Review
- Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review.Life (Basel, Switzerland) · 2024Review
- Delayed Antibody Response in the Acute Phase of Infection Is Associated with a Lower Mental Component of Quality of Life in Survivors of Severe and Critical COVID-19.Journal of clinical medicine · 2024Article
- Caveolin-1 mediates blood-brain barrier permeability, neuroinflammation, and cognitive impairment in SARS-CoV-2 infection.Journal of neuroimmunology · 2024Article
- The S1 subunits of SARS-CoV-2 variants differentially trigger the IL-6 signaling pathway in human brain endothelial cells and downstream impact on microglia activation.NeuroImmune pharmacology and therapeutics · 2024Article
- Traumatic Brain Injury in the Long-COVID Era.Neurotrauma reports · 2024Review
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Authors and funding
18 authors at 5 institutions in 3 countries.
Carolline Soares MottaLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0003-0489-9597
Silvia ToricesDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0001-8979-887X
Barbara Gomes da RosaLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-4026-5586
Anne Caroline MarcosLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Liandra Alvarez-RosaLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Michele SiqueiraLaboratório Compartilhado, Instituto de Ciências Biomédicas, UFRJ, Rio de Janeiro 05508-000, Brazil.
Thaidy Moreno-RodriguezUrology Department, University of California San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-3588-3889
Aline da Rocha MatosLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais (LVRE), Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0001-7763-2127
Braulia Costa CaetanoLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais (LVRE), Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Jessica Santa Cruz de Carvalho MartinsLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais (LVRE), Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Luis GladulichLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Erick LoiolaLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-7926-795X
Olivia R M BagshawFaculty of Mathematics & Science, Brock University, St. Catharines, ON L2S 3A1, Canada.
Jeffrey A StuartFaculty of Mathematics & Science, Brock University, St. Catharines, ON L2S 3A1, Canada.ORCID 0000-0001-5894-0300
Marilda M SiqueiraLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais (LVRE), Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.
Joice StipurskyLaboratório Compartilhado, Instituto de Ciências Biomédicas, UFRJ, Rio de Janeiro 05508-000, Brazil.ORCID 0000-0002-7917-6425
Michal ToborekDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.ORCID 0000-0003-4475-2119
Daniel AdesseLaboratório de Biologia Estrutural, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-7421-9510
Fundação Oswaldo Cruz · BRUniversidade Federal do Rio de Janeiro · BRUniversity of Miami · USBrock University · CAUniversity of California, San Francisco · US
Funding
University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8MTat, amyloid beta and brain endothelial barrier functionR01MH072567 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Michal Toborek · 2005 to 2026
$7.6MRole of cerebral vasculature in brain ischemia in HIV infectionR01HL126559 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2014 to 2024
$3.8MTo evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0MTargeting Inflammasomes in Substance Abuse and HIVR01DA050528 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2020 to 2024
$2.3MDefining brain pericytes as a novel and myeloid-derived HIV reservoirR01MH128022 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2021 to 2025
$2.3MPrevention of HIV and drug abuse-induced brain pathology by targeting mitochondriaR01DA044579 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2017 to 2021
$2.2MA new pathway of spinal neurons in neuropathic pain induced by HIV with opioidR01DA047157 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN · 2018 to 2022
$2.1MRole of the BBB in HIV brain infection during methamphetamine abuseR01DA039576 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2015 to 2019
$2.0MNovel role of inflammasome activation in ART neurotoxicityR21MH122235 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI TOBOREK, MICHAL · 2020 to 2021
$422kNHLBI NIH HHS R01 HL126559NIAID NIH HHS P30 AI073961NIDA NIH HHS R01 DA039576NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA044579NIDA NIH HHS R01 DA047157NIDA NIH HHS R01 DA050528NIH HHS MH128022, MH122235, MH072567, HL126559, DA044579, DA039576, DA040537, DA050528, R01HL126559-06S1 , DA047157NIMH NIH HHS R01 MH072567NIMH NIH HHS R01 MH128022NIMH NIH HHS R21 MH122235
Abstract
Neurological effects of COVID-19 and long-COVID-19, as well as neuroinvasion by SARS-CoV-2, still pose several questions and are of both clinical and scientific relevance. We described the cellular and molecular effects of the human brain microvascular endothelial cells (HBMECs
Indexed as
COVID-19NF-kappa BBlood-Brain BarrierBrainEndothelial CellsHumansMitochondriaPost-Acute COVID-19 SyndromeSARS-CoV-2NF-kappa Bblood–brain barrierCOVID-19endothelial activationmitochondrial dynamicsNF-κB signaling pathway
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.