Evidence map›Paper›PMID 36992426›Full record

ArticleViruses2023

Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age.

Francesco Nunziata, Simona Salomone, Andrea Catzola, Marco Poeta, Federica Pagano, Liana Punzi, Andrea Lo Vecchio, Alfredo Guarino, Eugenia Bruzzese

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Francesco NunziataDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7351-4104
Simona SalomoneDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.
Andrea CatzolaPediatric Unit, OORR Area Stabiese, Castellammare di Stabia, 80053 Naples, Italy.
Marco PoetaDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7515-1394
Federica PaganoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.
Liana PunziDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.
Andrea Lo VecchioDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.
Alfredo GuarinoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.
Eugenia BruzzeseDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-8578-729X
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the implementation of restrictive measures led to a dramatic reduction in respiratory syncytial virus (RSV) occurrence together with rare and mild bronchiolitis induced by SARS-CoV-2. We described the respiratory picture of SARS-CoV-2 infection and evaluated the frequency and the severity of SARS-CoV-2 bronchiolitis comparing it with other respiratory viral infections in children less than two years of age. The severity of respiratory involvement was evaluated based on the need for oxygen therapy, intravenous hydration, and the length of hospital stay. A total of 138 children hospitalized for respiratory symptoms were enrolled: 60 with SARS-CoV-2 and 78 with RSV. In the group of SARS-CoV-2-infected children, 13/60 (21%) received a diagnosis of co-infection. Among the enrolled children, 87/138 (63%) received a diagnosis of bronchiolitis. The comparative evaluation showed a higher risk of the need for oxygen therapy and intravenous hydration in children with RSV infection and co-infection compared to children with SARS-CoV-2 infection. In the children with a diagnosis of bronchiolitis, no differences in the main outcomes among the groups were observed. Although children with SARS-CoV-2 infection have less severe respiratory effects than adults, the pediatrician should pay attention to bronchiolitis due to SARS-CoV-2, which could have a severe clinical course in younger children.

Indexed as

BronchiolitisCoinfectionCOVID-19PneumoniaRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsVirus DiseasesChildHospitalizationHumansInfantOxygenSARS-CoV-2OxygenbronchiolitischildrenCOVID-19respiratory syncytial virusSARS-CoV-2

Identifiers

PMID36992426
PMCPMC10055850
OpenAlexW4323850608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.