Evidence map›Paper›PMID 36992386›Full record

ArticleViruses2023

Adjustment of Immunosuppressants to Facilitate Anti-COVID-19 Antibody Production after mRNA Vaccination in Liver Transplant Recipients.

Wei-Chen Lee, Hao-Chien Hung, Jin-Chiao Lee, Chung-Guei Huang, Po-Wei Huang, Po-Wen Gu, Yu-Chao Wang, Chih-Hsien Cheng, Tsung-Han Wu, Chen-Fang Lee and 3 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Wei-Chen LeeDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Hao-Chien HungDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0001-8830-3679
Jin-Chiao LeeDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0001-6075-8786
Chung-Guei HuangDepartment of Laboratory Medicine, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0002-0598-5684
Po-Wei HuangDepartment of Laboratory Medicine, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Po-Wen GuDepartment of Laboratory Medicine, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Yu-Chao WangDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Chih-Hsien ChengDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Tsung-Han WuDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0002-5083-8851
Chen-Fang LeeDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Ting-Jung WuDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0001-8911-8758
Hong-Shiue ChouDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.ORCID 0000-0002-3583-2048
Kun-Ming ChanDivision of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Taoyuan 33357, Taiwan.
Chang Gung University · TWChang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplant recipients are immunocompromised and have low immunogenicity to produce antibodies in anti-COVID-19 vaccination. Whether immunosuppressant adjustment could facilitate anti-COVID-19 antibody production in anti-COVID-19 mRNA vaccination is undetermined. Our patients were informed to temporarily suspend mycophenolate mofetil (MMF) or everolimus (EVR) for 2 weeks during both the 1st and 2nd doses of Moderna mRNA-1273 vaccine. A total of 183 recipients receiving two doses of Moderna mRNA-1273 vaccine were enrolled and grouped into tacrolimus monotherapy (MT,

Indexed as

COVID-19Liver Transplantation2019-nCoV Vaccine mRNA-1273Antibodies, ViralAntibody FormationEverolimusHumansImmunosuppressive AgentsLiving DonorsMycophenolic AcidRNA, MessengerTacrolimusTransplant RecipientsVaccination2019-nCoV Vaccine mRNA-1273Antibodies, ViralEverolimusImmunosuppressive AgentsMycophenolic AcidRNA, MessengerTacrolimusCOVID-19immunosuppressantliver transplantationModerna mRNA-1273 vaccinevaccine

Identifiers

PMID36992386
PMCPMC10051347
OpenAlexW4323314010

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.