Evidence map›Paper›PMID 36992372›Full record

ArticleViruses2023

Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43.

Virginia Fuochi, Giuseppe Floresta, Rosalia Emma, Vincenzo Patamia, Massimo Caruso, Chiara Zagni, Federica Ronchi, Celestino Ronchi, Filippo Drago, Antonio Rescifina and 1 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Virginia FuochiDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, 95124 Catania, Italy.ORCID 0000-0003-0405-5095
Giuseppe FlorestaDepartment of Drug and Health Sciences (DSFS), University of Catania, 95125 Catania, Italy.ORCID 0000-0002-0668-1260
Rosalia EmmaDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, 95124 Catania, Italy.
Vincenzo PatamiaDepartment of Drug and Health Sciences (DSFS), University of Catania, 95125 Catania, Italy.ORCID 0000-0002-0048-2631
Massimo CarusoDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, 95124 Catania, Italy.ORCID 0000-0002-4412-2080
Chiara ZagniDepartment of Drug and Health Sciences (DSFS), University of Catania, 95125 Catania, Italy.ORCID 0000-0003-1220-4281
Federica RonchiDelim Cosmetics & Pharma S.R.L., 20090 Vimodrone, MI, Italy.
Celestino RonchiDelim Cosmetics & Pharma S.R.L., 20090 Vimodrone, MI, Italy.
Filippo DragoDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, 95124 Catania, Italy.
Antonio RescifinaDepartment of Drug and Health Sciences (DSFS), University of Catania, 95125 Catania, Italy.ORCID 0000-0001-5039-2151
Pio Maria FurneriDepartment of Biomedical and Biotechnological Sciences (Biometec), University of Catania, 95124 Catania, Italy.ORCID 0000-0003-1782-9758
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is known that the spike protein of human coronaviruses can bind to a secondary receptor, or coreceptor, to facilitate the virus entry. While HCoV-229E uses human aminopeptidase N (hAPN) as a receptor, HCoV-OC43 binds to 9-

Indexed as

Coronavirus 229E, HumanCoronavirus OC43, HumanAnimalsEnoxaparinHeparan SulfateHumansMolecular Docking SimulationSpike Glycoprotein, CoronavirusEnoxaparinHeparan SulfateSpike Glycoprotein, Coronavirus9-O-Ac-SiaAPNcoronavirusenoxaparinHCoV-229EHCoV-OC43heparan sulfatemolecular docking

Identifiers

PMID36992372
PMCPMC10056857
OpenAlexW4322742062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.