Evidence map›Paper›PMID 36992341›Full record

ArticleViruses2023

Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling.

John Grayson Evans, Laura A Novotny, Eric G Meissner

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Mechanisms of Differential Signal Transduction by IFNLR1 Variants.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Function of Interferon Lambda Receptor 1 Variants in Stem Cell-Derived Hepatocytes with Abrogated EndogenousJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

John Grayson EvansDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave., MSC752, Charleston, SC 29425, USA.ORCID 0000-0002-3398-3037
Laura A NovotnyDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave., MSC752, Charleston, SC 29425, USA.ORCID 0000-0003-1717-8588
Eric G MeissnerDivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, 135 Rutledge Ave., MSC752, Charleston, SC 29425, USA.ORCID 0000-0002-5240-7115
Medical University of South Carolina · US

Funding

The role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jennifer Susan Stancill · 2020 to 2026
$18.7M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
South Carolina Clinical & Translational Research Institute (SCTR)TL1TR001451 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI FEGHALI-BOSTWICK, CAROL A. · 2015 to 2024
$4.6M
Novel Tools to Investigate Local and Global RNA Conformations in the SpliceosomeR00GM120457 · NIGMS · UNIVERSITY OF OREGON · PI WIDOM, JULIA REED · 2019 to 2021
$747k
Novel tools to investigate local and global RNA conformations in the spliceosomeK99GM120457 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WIDOM, JULIA REED · 2016 to 2017
$180k
NCATS NIH HHS TL1 TR001451NCATS NIH HHS TL1TR001451NIDDK NIH HHS P30 DK123704NIDDK NIH HHS P30DK123704NIGMS NIH HHS K99 GM120457NIGMS NIH HHS P20GM120457NIGMS NIH HHS P20 GM130457NIGMS NIH HHS R00 GM120457
6 · The paper itself

Abstract

Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple

Indexed as

Interferon LambdaReceptors, InterferonAntiviral Restriction FactorsHEK293 CellsHumansInterferonsProtein IsoformsAntiviral Restriction FactorsIFNLR1 protein, humanInterferon LambdaInterferonsProtein IsoformsReceptors, Interferonantiviralinflammationinnate immunityinterferon lambda receptor 1interferons

Identifiers

PMID36992341
PMCPMC10052089
OpenAlexW4322501165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.