ArticleVaccines2023
Outcomes of High-Grade Cervical Dysplasia with Positive Margins and HPV Persistence after Cervical Conization.
Open access · goldAbstract read
In one paragraph
Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 4 pooled it
14.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The Impact of Antiretroviral Therapy (ART) on HPV Persistence and Cervical Cancer Progression Among Women with HPV/HIV Co-infection: A Systematic Review.AIDS and behavior · 2025Pooled it
- The role of multiple high-risk human papillomavirus infection on the persistence recurrence of high-grade cervical lesions after standard treatment: A systematic review and a meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2024Pooled it
- Pooled it
- Trichomonas vaginalis infection and risk of cervical neoplasia: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix.Current medical science · 2024Trial
- Determinants of Cone Volume During Large Loop Excision of the Transformation Zone (LLETZ) and Their Association with Specimen Fragmentation and Excisional Margin-A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Effect of prophylactic HPV vaccination and timing of administration on recurrence of cervical HSIL after LEEP: A retrospective study.Medicine · 2026Article
- Informative HPV testing after conization and its impact on time-varying estimates: a GAMM-based cohort study.Frontiers in public health · 2026Article
- Bulk and single cell RNA sequencing data reveal lactylation-related gene signatures for prognosis and immunity in cervical cancer.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value.Discover oncology · 2024Article
- ECC at LLETZ-An Exploratory Retrospective Cohort Study.Journal of clinical medicine · 2024Article
- Genetic analysis of cervical cancer with lymph node metastasis.Journal of gynecologic oncology · 2024Article
- Trends in cervical cancer: A decade‑long analysis of incidence, survival and demographic disparities in a Northern Italian province.Molecular and clinical oncology · 2024Article
- Barriers and facilitators of retention in care after cervical cancer screening: patients' and healthcare providers' perspectives.BMC women's health · 2024Article
- Article
- Impact of Excision Type, Cone Volume, and Dimensions on Persistence/Recurrence of Cervical Intraepithelial Neoplasia 2-3.Life (Basel, Switzerland) · 2024Article
- Precancerous lesion determinants in women attending cervical cancer screening at public health facilities in North Shoa Zone, Amhara, Ethiopia: an unmatched case-control study.BMC women's health · 2024Article
- Cervical screening among Chinese females in the era of HPV vaccination: a population-based survey on screening uptake and regular screening following an 18-year organized screening program.Journal of gynecologic oncology · 2024Article
- Correlation of the HPV 16 Genotype Persistence in Women Undergoing LEEP for CIN3 with the Risk of CIN2+ Relapses in the First 18 Months of Follow-Up: A Multicenter Retrospective Study.Diagnostics (Basel, Switzerland) · 2024Article
- A retrospective study for long-term oncologic and obstetric outcomes in cervical intraepithelial neoplasia treated with loop electrosurgical excision procedure: focus on surgical margin and human papillomavirus.BMC women's health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors at 20 institutions in 1 country.
Andrea GianniniDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-4388-0082
Violante Di DonatoDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9254-5790
Francesco SopracordevoleGynecological Oncology Unit, Centro di Riferimento Oncologico-National Cancer Institute, 33081 Aviano, Italy.
Andrea CiavattiniWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60126 Ancona, Italy.
Alessandro GhelardiAzienda Usl Toscana Nord-Ovest, UOC Ostetricia e Ginecologia, Ospedale Apuane, 54100 Massa, Italy.
Enrico VizzaGynecologic Oncology Unit, Department of Experimental Clinical Oncology, IRCCS "Regina Elena" National Cancer Institute, 00144 Rome, Italy.
Ottavia D'OriaDepartment of Woman's and Child's Health, Obstetrics and Gynecological Unit, San Camillo-Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0002-3482-1523
Tommaso SimonciniDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-2971-0079
Francesco PlottiDepartment of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Jvan CasarinDepartment of Obstetrics and Gynecology, 'Filippo Del Ponte' Hospital, University of Insubria, 21100 Varese, Italy.
Tullio Golia D'AugèDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-1018-3088
Ilaria CuccuDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Maurizio SeratiDepartment of Obstetrics and Gynecology, 'Filippo Del Ponte' Hospital, University of Insubria, 21100 Varese, Italy.
Ciro PinelliOspedale di Circolo Fondazione Macchi, 21100 Varese, Italy.
Alice BergaminiDepartment of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, 20100 Milano, Italy.
Barbara GardellaIRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy.ORCID 0000-0002-0812-8995
Andrea Dell'AcquaGynaecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Ermelinda MontiGynaecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Paolo VercelliniGynaecology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Giovanni D'IppolitoDivision of Obstetrics and Gynecology, Cesare Magati Hospital, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42019 Scandiano, Italy.ORCID 0000-0003-0050-4498
Lorenzo AguzzoliDivision of Obstetrics and Gynecology, Cesare Magati Hospital, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42019 Scandiano, Italy.
Vincenzo Dario MandatoDivision of Obstetrics and Gynecology, Cesare Magati Hospital, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42019 Scandiano, Italy.ORCID 0000-0001-6537-1046
Luca GiannellaWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-6405-8522
Cono ScaffaGynecology Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-6012-190X
Antonino DittoGynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.
Francesca FalconeGynecology Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.ORCID 0000-0002-3729-2321
Chiara BorghiDepartment of Obstetrics and Gynecology, S. Anna University Hospital, 44121 Ferrara, Italy.
Mario MalzoniEndoscopica Malzoni, Center for Advanced Endoscopic Gynecological Surgery, 83100 Avellino, Italy.
Alessandra Di GiovanniEndoscopica Malzoni, Center for Advanced Endoscopic Gynecological Surgery, 83100 Avellino, Italy.
Maria Giovanna SalernoDepartment of Woman's and Child's Health, Obstetrics and Gynecological Unit, San Camillo-Forlanini Hospital, 00152 Rome, Italy.
Viola LiberaleDepartment of Obstetrics and Gynecology, Ospedale Maria Vittoria, 10144 Torino, Italy.
Biagio ContinoDepartment of Obstetrics and Gynecology, Ospedale Maria Vittoria, 10144 Torino, Italy.
Cristina DonfrancescoDepartment of Obstetrics and Gynecology, Azienda ASL Frosinone, Ospedale S Trinità di Sora, 03039 Sora, Italy.
Michele DesiatoDepartment of Obstetrics and Gynecology, Azienda ASL Frosinone, Ospedale S Trinità di Sora, 03039 Sora, Italy.
Anna Myriam PerroneGynecologic Oncology Unit, Sant'Orsola-Malpighi Hospital, 40138 Bologna, Italy.ORCID 0000-0003-3140-4772
Pierandrea De IacoGynecologic Oncology Unit, Sant'Orsola-Malpighi Hospital, 40138 Bologna, Italy.
Simone FerreroAcademic Unit of Obstetrics and Gynaecology, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-2225-5568
Giuseppe SarpietroDepartment of General Surgery and Medical Surgical Specialties, Gynecological Clinic University of Catania, Via S. Sofia 78, 95124 Catania, Italy.ORCID 0000-0003-4891-9000
Maria G MatarazzoDepartment of General Surgery and Medical Surgical Specialties, Gynecological Clinic University of Catania, Via S. Sofia 78, 95124 Catania, Italy.
Antonio CianciDepartment of General Surgery and Medical Surgical Specialties, Gynecological Clinic University of Catania, Via S. Sofia 78, 95124 Catania, Italy.
Stefano CianciDepartment of Gynecologic Oncology, Università degli Studi di Messina, Policlinico G. Martino, 98122 Messina, Italy.
Sara BosioSan Paolo Hospital, Università degli Studi di Milano, 20142 Milan, Italy.
Simona RuisiSan Paolo Hospital, Università degli Studi di Milano, 20142 Milan, Italy.
Lavinia MoscaDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Raffaele TinelliDepartment of Obstetrics and Gynecology, "Valle d'Itria" Hospital, Martina Franca, Via San Francesco da Paola, 74015 Taranto, Italy.ORCID 0000-0001-5597-3035
Rosa De VincenzoUOC Ginecologia Oncologica, Dipartimento per la Salute Della Donna e del Bambino e Della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.ORCID 0000-0001-7408-0435
Gian Franco ZannoniUOC Ginecologia Oncologica, Dipartimento per la Salute Della Donna e del Bambino e Della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Gabriella FerrandinaUOC Ginecologia Oncologica, Dipartimento per la Salute Della Donna e del Bambino e Della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Marco PetrilloGynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-0306-4328
Giampiero CapobiancoGynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-5523-8943
Annunziata CarleaDepartment of Neuroscience, Reproductive Science and Dentistry, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0003-2607-0528
Fulvio ZulloDepartment of Neuroscience, Reproductive Science and Dentistry, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Barbara MuschiatoStudio Medico Muschiato, Loano & Finale Ligure, 17025 Loano, Italy.
Stefano PalombaUnit of Obstetrics and Gynecology, GOM of Reggio Calabria & University 'Magna Graecia' of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-2767-8295
Stefano GreggiGynecology Oncology Unit, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131 Naples, Italy.
Arsenio SpinilloIRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy.
Fabio GhezziDepartment of Obstetrics and Gynecology, 'Filippo Del Ponte' Hospital, University of Insubria, 21100 Varese, Italy.
Nicola ColacurciDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Roberto AngioliDepartment of Obstetrics and Gynecology, Campus Bio-Medico University of Rome, 00128 Rome, Italy.
Pierluigi Benedetti PaniciDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Ludovico MuziiDepartment of Gynecological, Obstetrical and Urological Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7195-9583
Giovanni ScambiaUOC Ginecologia Oncologica, Dipartimento per la Salute Della Donna e del Bambino e Della Salute Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy.
Francesco RaspagliesiGynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.
Giorgio BoganiGynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.ORCID 0000-0001-8373-8569
Sapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Catania · ITUniversity of Insubria · ITCarlo Forlanini Hospital · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITMarche Polytechnic University · ITOspedale Maria Vittoria · ITUniversità Campus Bio-Medico · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Milan · ITUniversity of Naples Federico II · ITUniversity of Pavia · ITUniversity of Sassari · ITAzienda Usl Toscana Centro · ITCentro di Riferimento Oncologico · IT
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this work is to assess the 5-year outcomes of patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in the persistence of HPV infection and the positivity of surgical resection margins. This is a retrospective study evaluating patients undergoing conization for high-grade cervical lesions. All patients included had both positive surgical margins and experienced HPV persistence at 6 months. Associations were evaluated with Cox proportional hazard regression and summarized using hazard ratio (HR). The charts of 2966 patients undergoing conization were reviewed. Among the whole population, 163 (5.5%) patients met the inclusion criteria, being at high risk due to the presence of positive surgical margins and experiencing HPV persistence. Of 163 patients included, 17 (10.4%) patients developed a CIN2+ recurrence during the 5-year follow-up. Via univariate analyses, diagnosis of CIN3 instead of CIN2 (HR: 4.88 (95%CI: 1.10, 12.41);
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conizationHPVHPV persistencepositive margins
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