Evidence map›Paper›PMID 36992254›Full record

ArticleVaccines2023

BMI-Associated Anti-Apolipoprotein A-1 Positivity in Healthy Adults after mRNA-Vaccination against COVID-19.

Roman Máčalík, Marek Petráš, Alexander M Čelko, Petr Chmátal, Jakub Tlapák, Pavel Dlouhý, Jana Malinová, Ivana Králová Lesná

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Roman MáčalíkThird Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0002-2166-9403
Marek PetrášThird Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0003-2913-1736
Alexander M ČelkoThird Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.ORCID 0000-0002-9031-055X
Petr ChmátalInstitute of Aviation Medicine, 160 00 Prague, Czech Republic.
Jakub TlapákInstitute of Aviation Medicine, 160 00 Prague, Czech Republic.ORCID 0000-0002-7706-7647
Pavel DlouhýThird Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.
Jana MalinováKrálovské Vinohrady University Hospital, 100 34 Prague, Czech Republic.
Ivana Králová LesnáInstitute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.ORCID 0000-0002-9053-4123
Charles University · CZInstitute of Aviation Medicine · CZUniversity Hospital Kralovske Vinohrady · CZ

Funding

Cooperatio 31 fund, Health Sciences, Charles University, Prague, Czech Republic not applicable
6 · The paper itself

Abstract

Elevated anti-apolipoprotein A-1 (AAA1) antibody levels associated with cardiovascular risk have been observed in previously SARS-CoV-2-infected or COVID-19-vaccinated individuals. Since patient safety is generally a priority in vaccination, we sought to investigate AAA1 antibody levels in healthy adults after mRNA vaccination. We conducted a prospective cohort study in healthy adult volunteers recruited from military workers of the Transport Air Base in Prague who had received two doses of mRNA vaccines. Anti-apolipoprotein A-1 antibody levels were determined using ELISA from serum samples obtained at three and four time points after the first and second vaccine doses, respectively, within almost 17 weeks of follow-up. The transient AAA1 positivity rate achieved 24.1% (95% confidence interval CI: 15.4-34.7%), i.e., 20 out of 83 participants had at least one positive post-vaccination sample, with a repeat positivity confirmed in only 5 of them. This rate was associated with a BMI > 26 kg/m

Indexed as

anti-apolipoprotein A-1autoantibodyBMImRNA vaccinationobesity

Identifiers

PMID36992254
PMCPMC10053701
OpenAlexW4327596678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.