Evidence map›Paper›PMID 36992160›Full record

ReviewVaccines2023

Encephalitis following COVID-19 Vaccination: A Systematic Review.

Mariam Abdelhady, Muhammad Ashraf Husain, Yousef Hawas, Mahmoud Abdelsalam Elazb, Lena Said Mansour, Mohamed Mohamed, Maya Magdy Abdelwahab, Ahmed Aljabali, Ahmed Negida

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Post-COVID-19 Vaccination CNS Magnetic Resonance Imaging Findings: A Systematic Review.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Mariam AbdelhadyFaculty of Medicine, October 6 University, Giza 12585, Egypt.
Muhammad Ashraf HusainFaculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.ORCID 0009-0006-3392-0278
Yousef HawasFaculty of Medicine, Tanta University, Tanta 31511, Egypt.
Mahmoud Abdelsalam ElazbMedical Research Group of Egypt (MRGE), Cairo 11511, Egypt.ORCID 0000-0003-1458-6201
Lena Said MansourInternal Medicine Department, Damanhour Teaching Hospital, Damanhour 22511, Egypt.
Mohamed MohamedFaculty of Medicine, Zagazig University, Zagazig 44519, Egypt.
Maya Magdy AbdelwahabFaculty of Medicine, Helwan University, Cairo 11795, Egypt.ORCID 0000-0003-4789-4307
Ahmed AljabaliFaculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Ahmed NegidaMedical Research Group of Egypt (MRGE), Cairo 11511, Egypt.ORCID 0000-0001-5363-6369
Al-Azhar University · EGDamanhour University · EGHarvard University · USHelwan University · EGJordan University of Science and Technology · JOScientific Research Group in Egypt · EGTanta University · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince the advent of global COVID-19 vaccination, several studies reported cases of encephalitis with its various subtypes following COVID-19 vaccinations. In this regard, we conducted a systematic review to investigate and characterize the clinical settings of these reported cases to aid in physician awareness and proper care provision.

methodsWe systematically searched PubMed, Web of Science, and Scopus and manually searched Google Scholar. Studies published until October 2022 were included. Demographic data, clinical features, vaccine data, treatment lines, and outcomes were extracted.

resultsA total of 65 patients from 52 studies were included. The mean age of patients was 46.82 ± 19.25 years, 36 cases (55.4%) were males. AstraZeneca was the most-reported vaccine associated with encephalitis (38.5%) followed by Pfizer (33.8%), Moderna (16.9%), and others. Moat encephalitis cases occurred after the first dose of vaccination in 41/65 (66.1%). The mean time between vaccination and symptom onset was 9.97 ± 7.16 days. Corticosteroids (86.2 %) and immunosuppressants (81.5 %) were the most used lines of treatment. The majority of affected individuals experienced a full recovery.

conclusionOur study summarizes the current evidence of reported post-vaccination encephalitis, regarding clinical presentation, symptoms onset, management, outcomes, and comorbid conditions; however, it fails to either acknowledge the incidence of occurrence or establish a causal relationship between various COVID-19 vaccines and encephalitis.

Indexed as

adverse effectsCOVID-19 vaccineencephalitissystematic review

Identifiers

PMID36992160
PMCPMC10054808
OpenAlexW4323047570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.