Evidence map›Paper›PMID 36992109›Full record

ArticleVaccines2023

A Polysaccharide-RBD-Fc-Conjugated COVID-19 Vaccine, SCTV01A, Showed High Immunogenicity and Low Toxicity in Animal Models.

Chunyun Sun, Desheng Kong, Erhong Guo, Jun Zhao, Jilei Jia, Rui Wang, Juan Ma, Meng Chen, Jianbo Lu, Chulin Yu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Chunyun SunBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Desheng KongBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Erhong GuoBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Jun ZhaoBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Jilei JiaBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Rui WangBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Juan MaBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Meng ChenBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Jianbo LuBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Chulin YuBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Kuokuo LiBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Liangzhi XieBeijing Engineering Research Center of Protein and Antibody, Sinocelltech Ltd., Beijing 100176, China.
Sinocelltech Group (China) · CN

Funding

Beijing Municipal Science and Technology Program Z211100002521026
6 · The paper itself

Abstract

We previously developed a polysaccharide--RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. Here, we newly developed a vaccine, SCTV01A, by chemically conjugating recombinant SARS-CoV-2 RBD-Fc and PPS14 (

Indexed as

conjugated vaccineCOVID-19immunogenicitySARS-CoV-2toxicity

Identifiers

PMID36992109
PMCPMC10052645
OpenAlexW4321616928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.