SynthesisWorld journal of emergency surgery : WJES2023
Effectiveness of intraoperative peritoneal lavage with saline in patient with intra-abdominal infections: a systematic review and meta-analysis.
Synthesis in World journal of emergency surgery : WJES, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Efficacy and safety of hyperthermic intraperitoneal intraoperative chemotherapy plus surgery in advanced ovarian cancer patients.The Journal of international medical research · 2025Trial
- Global practices and attitudes in acute appendicitis management: the PAMAP-W international survey and Delphi consensus study on the WSES appendicitis grading system.World journal of emergency surgery : WJES · 2026Article
- Understanding the composite failure rate of the step-up approach in infected necrotizing pancreatitis: a scoping review.Updates in surgery · 2026Review
- Association between intraoperative irrigation volume and postoperative abdominal abscess in perforated peptic ulcer.BMC surgery · 2026Article
- Saline solution vs. stabilized isotonic sodium hypochlorite lavage in complicated appendicitis: a comparative study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Postoperative enteral nutrition timing and risk variation in elderly patients with perforated peptic ulcer.Frontiers in nutrition · 2026Article
- Diagnosis and surgical management of septic peritonitis in small animals: A review.Veterinary surgery : VS · 2026Review
- COVID-19-specific risk factor for early post-appendectomy complications (EPAC) in older patients: a retrospective study.Techniques in coloproctology · 2025Observational
- Feasibility of Low-Volume Atomized Povidone-Iodine as a Peritoneal Antiseptic in Complicated Appendicitis.The Journal of surgical research · 2025Article
- Peritoneal Lavage With Low GDP Neutral pH PD Solution Reduces Mortality and Severity in a Lethal Peritonitis Model.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025Article
- Iatrogenic cecal perforation after abdominal drain placement on a horse.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- The clinical significance of intraoperative lavage fluid culture during pancreaticoduodenectomy on organ/space surgical site infection.Scientific reports · 2024Article
- Intra-operative peritoneal lavage: normal saline, super-oxidized solution, antibiotics, or chemotherapy dilemma.Annals of medicine and surgery (2012) · 2023Article
Corrections and comments
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Authors and funding
17 authors at 10 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative peritoneal lavage (IOPL) with saline has been widely used in surgical practice. However, the effectiveness of IOPL with saline in patients with intra-abdominal infections (IAIs) remains controversial. This study aims to systematically review randomized controlled trials (RCTs) evaluating the effectiveness of IOPL in patients with IAIs.
methodsThe databases of PubMed, Embase, Web of Science, Cochrane library, CNKI, WanFang, and CBM databases were searched from inception to December 31, 2022. Random-effects models were used to calculate the risk ratio (RR), mean difference, and standardized mean difference. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the quality of the evidence.
resultsTen RCTs with 1318 participants were included, of which eight studies on appendicitis and two studies on peritonitis. Moderate-quality evidence showed that the use of IOPL with saline was not associated with a reduced risk of mortality (0% vs. 1.1%; RR, 0.31 [95% CI, 0.02-6.39]), intra-abdominal abscess (12.3% vs. 11.8%; RR, 1.02 [95% CI, 0.70-1.48]; I
conclusionIOPL with saline use in patients with appendicitis was not associated with significantly decreased risk of mortality, intra-abdominal abscess, incisional surgical site infection, postoperative complication, reoperation, and readmission compared with non-IOPL. These findings do not support the routine use of IOPL with saline in patients with appendicitis. The benefits of IOPL for IAI caused by other types of abdominal infections need to be investigated.
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