Trial reportBMC pediatrics2023
Efficacy and safety of mucous fistula refeeding in preterm infants: an exploratory randomized controlled trial.
Trial report in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02812095 (Efficacy and Safety of Refeeding in Preterm Infants With Enterostomy), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Refeeding in Preterm Infants With Enterostomy
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Mucous Fistula Refeeding in Newborns: Why, When, How, and Where? Insights from a Systematic Review.Nutrients · 2025Pooled it
- Sepsis profile among preterm infants with enterostomy and fecal transfer: a multicenter retrospective cohort study.Molecular and cellular pediatrics · 2026Article
- Flow efficiency of 3D-printed refeeding tubes in a simulated neonatal high-output stoma model.Pediatric surgery international · 2026Article
- Clinical guideline for postoperative nutrition support in neonates with enterostomy (2024).Pediatric investigation · 2025Article
- Chyme reinfusion practices in the neonatal population.Pediatric surgery international · 2024Article
- A neonatal intensive care nurse experience of an automated chyme reinfusion therapy device: A case report describing use in a neonate with necrotising enterocolitis.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate whether mucous fistula refeeding (MFR) is safe and beneficial for the growth and intestinal adaptation of preterm infants with enterostomies.
methodsThis exploratory randomized controlled trial enrolled infants born before 35 weeks' gestation with enterostomy. If the stomal output was ≥ 40 mL/kg/day, infants were assigned to the high-output MFR group and received MFR. If the stoma output was < 40 mL/kg/day, infants were randomized to the normal-output MFR group or the control group. Growth, serum citrulline levels, and bowel diameter in loopograms were compared. The safety of MFR was evaluated.
resultsTwenty infants were included. The growth rate increased considerably, and the colon diameter was significantly larger after MFR. However, the citrulline levels did not significantly differ between the normal-output MFR and the control group. One case of bowel perforation occurred during the manual reduction for stoma prolapse. Although the association with MFR was unclear, two cases of culture-proven sepsis during MFR were noted.
conclusionsMFR benefits the growth and intestinal adaptation of preterm infants with enterostomy and can be safely implemented with a standardized protocol. However, infectious complications need to be investigated further.
trial registrationclinicaltrials.gov NCT02812095, retrospectively registered on June 6, 2016.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.