Evidence map›Paper›PMID 36991350›Full record

Trial reportBMC medical research methodology2023

Recruitment to a trial of antipsychotic reduction: impact of an acceptability study.

Georgina Ramsay, Zoë Haime, Nadia E Crellin, Jacki L Stansfeld, Stefan Priebe, Maria Long, Joanna Moncrieff

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medical research methodology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Georgina RamsayResearch and Development, North East London NHS Foundation Trust, Ilford, Essex, UK.
Zoë HaimeUniversity College London, Bloomsbury , UK.
Nadia E CrellinNuffield Trust, East London, UK.
Jacki L StansfeldResearch and Development, North East London NHS Foundation Trust, Ilford, Essex, UK.
Stefan PriebeUnit for Social and Community Psychiatry, Queen Mary University of London, Mile End, East London, UK.
Maria LongResearch and Development, North East London NHS Foundation Trust, Ilford, Essex, UK.
Joanna MoncrieffResearch and Development, North East London NHS Foundation Trust, Ilford, Essex, UK. j.moncrieff@ucl.ac.uk.
University College London · GBBury College · GBNorth East London NHS Foundation Trust · GBNuffield Trust · GBQueen Mary University of London · GB

Funding

Department of Health
6 · The paper itself

Abstract

objectivesPre-trial acceptability studies may boost recruitment, especially in trials comparing distinctly different interventions. We evaluated the impact of an acceptability study on recruitment to a randomised trial of antipsychotic reduction versus maintenance treatment and explored demographic and clinical predictors of subsequent enrolment.

methodsParticipants with a diagnosis of a schizophrenia spectrum disorder who were taking antipsychotic medication were interviewed about their views of taking part in a future trial.

resultsIn a sample of 210 participants, 151 (71.9%) expressed an interest in taking part in the future trial, 16 (7.6%) said they might be interested, and 43 (20.5%) said they were not. Altruistic reasons were most commonly given for wanting to take part, and concern about randomisation for not wanting to. Ultimately 57 people enrolled in the trial (27.1% of the original sample). Eighty-five people who initially expressed an interest did not enrol due to declining or not being eligible (for clinical reasons). Women and people from a white ethnic background were more likely to enrol in the trial, but no illness or treatment-related characteristics were associated with enrolment.

conclusionAn acceptability study can be a useful tool for recruitment to challenging trials, but it may over-estimate recruitment.

Indexed as

Antipsychotic AgentsSchizophreniaFemaleHumansAntipsychotic AgentsAcceptability studyPsychotic disordersRandomised controlled trialsRCTRecruitmentSchizophrenia

Identifiers

PMID36991350
PMCPMC10053425
OpenAlexW4361284030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.