ArticleMolecular psychiatry2024
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis.
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Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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18citing papers in PubMed, 1 pooled it
8.5field-weighted citation impact, top 2% of its field
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Lithium effects in the frontolimbic circuitry: a systematic review of neuroimaging findings in bipolar disorder.Translational psychiatry · 2026Pooled it
- Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium.Molecular psychiatry · 2026Article
- Multi-omics approaches to major psychiatric disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Review
- Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia.Molecular psychiatry · 2025Article
- Cellular and proteomic differences associated with lithium response in olfactory neuroepithelium cells of bipolar disorder patients.Molecular medicine (Cambridge, Mass.) · 2025Article
- Alterations of plasma neural-derived extracellular vesicles microRNAs in patients with bipolar disorder.Psychological medicine · 2025Article
- Designing and characterizing first Iranian study evaluating serum levels of lithium in patients for population pharmacokinetics (FIRELOLIPOP): baseline and first report.Scientific reports · 2025Article
- Model systems for emulating human tissue and physiology in psychiatric research.Frontiers in neuroscience · 2025Review
- Human-Induced Pluripotent Stem Cell (iPSC)-Derived GABAergic Neuron Differentiation in Bipolar Disorder.Cells · 2024Article
- New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview.Pharmacological reviews · 2024Review
- Possible Role of Correlation Coefficients and Network Analysis of Multiple Intracellular Proteins in Blood Cells of Patients with Bipolar Disorder in Studying the Mechanism of Lithium Responsiveness: A Proof-Concept Study.Journal of clinical medicine · 2024Article
- Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium.Molecular psychiatry · 2024Article
- Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.Translational psychiatry · 2024Article
- Pharmacogenomics and response to lithium in bipolar disorder.Pharmacogenomics · 2024Review
- Bipolar Disorder.Current opinion in neurobiology · 2023Review
- Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.Research square · 2023Article
- RNA Biomarkers in Bipolar Disorder and Response to Mood Stabilizers.International journal of molecular sciences · 2023Review
- On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol.PloS one · 2023Article
Corrections and comments
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Authors and funding
55 authors at 20 institutions in 5 countries.
Vipavee NiemsiriDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Sara Brin RosenthalCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5766-8923
Adam X MaihoferDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Maria C MarchettoDepartment of Anthropology, University of California, San Diego, La Jolla, CA, USA.
Renata SantosLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-3085-5128
Tatyana ShekhtmanDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-8594-5676
Amit AnandDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yokesh BalaramanDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Wade H BerrettiniDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Holli BertramDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Katherine E BurdickDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph R CalabreseMood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Cynthia V CalkinDepartment of Psychiatry and Medical Neuroscience, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-4673-3990
Carla ConroyMood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
William H CoryellDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Anna DeModenaPsychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.
Lisa T EylerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Scott FeederDepartment of Psychiatry, The Mayo Clinic, Rochester, MN, USA.
Carrie FisherDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Nicole FrazierDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Mark A FryeDepartment of Psychiatry, The Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-6997-4215
Keming GaoMood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Julie GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-7987-4995
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-6262-8264
Toyomi GotoMood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Gloria J HarringtonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Petter JakobsenNorment, Division of Psychiatry, Haukeland University Hospital and Department of Clinical medicine, University of Bergen, Bergen, Norway.
Masoud KamaliDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1453-5201
Marisa KellyDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7151-1938
Susan G LeckbandPsychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA.
Falk W LohoffDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0480-7755
Michael J McCarthyDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Melvin G McInnisDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-0375-6247
David CraigDepartment of Translational Genomics, University of Southern California, Los Angeles, CA, USA.
Caitlin E MillettDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Francis MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Gunnar MorkenDivision of Mental Health Care, St Olavs University Hospital, and Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Claire O' DonovanDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Ketil J ØedegaardNorment, Division of Psychiatry, Haukeland University Hospital and Department of Clinical medicine, University of Bergen, Bergen, Norway.
Kelly RyanDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Martha SchinagleMood Disorders Program, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Paul D ShillingDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0129-5504
Claire SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Emma K StappDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0628-0704
Andrea StautlandDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-6595-3692
Bruce TarwaterDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Peter P ZandiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0001-9544-3944
Kathleen M FischCenter for Computational Biology and Bioinformatics, University of California, San Diego, La Jolla, CA, USA.
Fred H GageLaboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-0938-4106
John R KelsoeDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA. jkelsoe@health.ucsd.edu.
University of California San Diego · USUniversity of Michigan · USDalhousie University · CAJohns Hopkins University · USBrigham and Women's Hospital · USIndiana University School of MedicineSalk Institute for Biological Studies · USUniversity Hospitals of Cleveland · USHaukeland University Hospital · NOMayo Clinic · USUniversity of Iowa · USUniversity of Pennsylvania · USUniversity School · USVA San Diego Healthcare System · USHarvard University · USNorthwestern University · USNorwegian University of Science and Technology · NOUC San Diego Health System · USUniversity of Bergen · NOUniversity of Chicago · US
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MClinical Genomics and Experimental TherapeuticsZIAAA000242 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOHOFF, FALK · 2015 to 2025
$26.7MRole of CACNA1C - a shared risk gene in neuropsychiatric disordersU19MH106434 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI O'SHEA, K SUE SUE · 2016 to 2020
$13.8MFellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3MSingle-Cell Approaches to Reveal How Jumping Genes Individualize Neural CircuitsR01MH095741 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GAGE, FRED H · 2011 to 2015
$6.5MPharmacogenomics of Mood Stabilizer Response in Bipolar DisorderU01MH092758 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 2010 to 2014
$6.2MBLRD VA I01 BX003431NCATS NIH HHS UL1 TR001442NIMH NIH HHS R01 MH095741NIMH NIH HHS T32 MH018399NIMH NIH HHS U01 MH092758NIMH NIH HHS U19 MH106434
Abstract
Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless of lithium exposure. In the PGBD, post-GWAS gene prioritization using the GWA-boosting (GWAB) approach identified 1119 candidate genes. Following DE-derived network propagation, there was a highly significant overlap of genes between the top 500- and top 2000-proximal gene networks and the GWAB gene list (P
Indexed as
Bipolar DisorderFocal AdhesionsGene Regulatory NetworksGenome-Wide Association StudyLithiumTranscriptomeAntimanic AgentsFemaleGene Expression ProfilingGenomicsHumansInduced Pluripotent Stem CellsLithium CompoundsMaleMultiomicsNeuronsAntimanic AgentsLithiumLithium Compounds
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