ArticleNature2023
Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
17.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 114 citations in OpenAlex.
- Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation.Signal transduction and targeted therapy · 2026Review
- Renal-clearable fluorescent probe for early detection of pancreatic cancer in living murine models.Science advances · 2026Article
- Rewiring glucose metabolism in pancreatic cancer by natural compounds: implications for immune evasion and therapeutic targets.Molecular biology reports · 2026Review
- Polyamines in CNS malignancies: positively charged culprits in the hijacking of neural and immune signaling pathways.Amino acids · 2026Review
- Article
- Alterations in gut microbiota and metabolic profiling are associated with papillary thyroid cancer and BRAFEndocrine · 2026Article
- Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications.Amino acids · 2026Review
- ARID1A deficiency-driven reprogramming of polyamine metabolism promotes endometrial cancer malignancy and immune escape.Cell death & disease · 2026Article
- Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.Nature communications · 2026Article
- PanMETAI - a high performance tabular foundation model for accurate pancreatic cancer diagnosis via NMR metabolomics.Nature communications · 2026Article
- Metabolic reprogramming in cancer: signaling pathways and therapeutic targets.Molecular cancer · 2026Review
- Metabolic Landscape of Endometrial Cancer: Insights into Pathway Dysregulation and Metabolic Features.Biomedicines · 2026Article
- Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Targeted Accumulation of Reactive Acrolein via Nanoparticle-embedded Reverse Temperature Hydrogel for Bladder Cancer Treatment.Theranostics · 2026Article
- The Multi-dimensional Mechanisms and Transformation Prospects of the Intratumoral Microbiota-Arginine Metabolism Axis in Tumor Progression and Immune Regulation.International journal of medical sciences · 2026Review
- Targeting the gut-pancreatic axis: microbial modulation of immunotherapy in pancreatic cancer.Frontiers in immunology · 2026Review
- Polyamines in Cancer: Mechanisms, Metabolic Targets, and Therapeutic Opportunities.Anti-cancer agents in medicinal chemistry · 2026Review
- KRAS-driven cytokine-metabolic crosstalk shapes immune exclusion in pancreatic ductal adenocarcinoma.Frontiers in genetics · 2026Review
- Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation.Nature communications · 2025Article
- Senescence-driven molecular subtyping in pancreatic cancer: a multi-omics framework for precision medicine.BMC cancer · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
19 authors at 5 institutions in 1 country.
Min-Sik LeeDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0563-8113
Courtney DennisMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Insia NaqviDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Lucas DaileyMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3204-9565
Alireza LorzadehDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
George YeDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1380-7121
Tamara ZaytouniDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7411-8915
Ashley AdlerDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Daniel S HitchcockMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lin LinDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Megan T HoffmanDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0907-9977
Aladdin M BhuiyanDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jaimie L BarthDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Miranda E MachacekDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1067-0561
Mari Mino-KenudsonDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9092-2265
Stephanie K DouganDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2263-363X
Unmesh JadhavDepartment of Stem Cell Biology and Regenerative Medicine, Broad-CIRM Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Clary B ClishMetabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8259-9245
Nada Y KalaanyDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA. nada.kalaany@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-7489-1035
Broad Institute · USHarvard University · USUniversity of Southern California · USBoston Children's Hospital · USMassachusetts General Hospital · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MRole of Altered Nutrient Metabolism in Pancreatic CancerR01CA270110 · NCI · BOSTON CHILDREN'S HOSPITAL · PI Nada Y. Kalaany · 2022 to 2026
$2.6MTraining in Developmental Biology, Stem Cells and RegenerationT32HD060549 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Gage D Crump · 2011 to 2026
$2.5MCDK4/6 inhibition during CD8 T cell priming potentiates memory formation in mice and humansR01AI158488 · NIAID · DANA-FARBER CANCER INST · PI DOUGAN, STEPHANIE · 2021 to 2025
$2.2MREPLICATION AND EXPRESSION OF HERPES SIMPLEX VIRUS DNAR01AI015488 · NIAID · UNIVERSITY OF CHICAGO · PI ROIZMAN, BERNARD · 1985 to 1991
–NCI NIH HHS R01 CA270110NIAID NIH HHS 1R01 AI15488-01NIAID NIH HHS R01 AI158488NICHD NIH HHS T32 HD060549NIDDK NIH HHS P30 DK040561
Abstract
There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA), a highly lethal malignancy with increasing incidence
Indexed as
Ornithine-Oxo-Acid TransaminasePancreatic NeoplasmsPolyaminesAnimalsArginineCarcinoma, Pancreatic DuctalHumansMiceOrnithineProto-Oncogene Proteins p21(ras)Tumor MicroenvironmentArginineHras protein, mouseKRAS protein, humanOAT protein, humanOrnithineOrnithine-Oxo-Acid TransaminasePolyaminesProto-Oncogene Proteins p21(ras)
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.