ArticleNature2023
Spatial multiomics map of trophoblast development in early pregnancy.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 2 pooled it
78.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
161 citing papers in PubMed, 2 syntheses or guidelines pooled it, 261 citations in OpenAlex.
- Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies.Human reproduction update · 2024Pooled it
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.PLoS genetics · 2023Pooled it
- Structural Control of Stromal-Immune Coupling by COL24A1 Underlies Pregnancy Maintenance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Predictive Value of Uterine Artery Pulsatility Index in Placental Insufficiency Across Gestational Stages in a Single Population.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Large-Pore Channels at the Maternal-Fetal Interface: Progress and Open Research Avenues.Biology · 2026Review
- Regulation of PDGF-BB signaling in placental pericytes by soluble PDGFRβ isoforms: implications for fetoplacental vascular development.Angiogenesis · 2026Article
- Spatial Transcriptomics-Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication.Advanced healthcare materials · 2026Article
- Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming Innovations.Biomedicines · 2026Review
- Decoding Cellular Heterogeneity with Microfluidic Single-Cell Secretion Analysis Tools.ACS omega · 2026Review
- Spatially resolved fetal and maternal cell contributions to severe preeclampsia across gestation.Science advances · 2026Article
- The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion.iScience · 2026Article
- aPKC-ζ III promotes trophoblast fusion by altering Par-3 interactions with Hippo signaling kinase LATS1.Stem cell reports · 2026Article
- Role of the trophoblastic BMP7-TGM2 axis in the pathogenesis and prevention of preeclampsia.Cell death & disease · 2026Article
- Dissecting human organ development using spatial technologies.Developmental cell · 2026Review
- Spotlight on challenges and novel methods in highly multiplexed tissue imaging-based spatial proteomics.Journal of translational medicine · 2026Review
- Remodeling lesions locate at sites of strong extravillous trophoblast invasion and are associated with neutrophil presence in the human first-trimester decidua.Human reproduction (Oxford, England) · 2026Article
- Single-nucleus multi-omics dissection of dysregulated trophoblast development and disrupted immune microenvironment in complete hydatidiform moles.Science China. Life sciences · 2026Article
- A longitudinal single-nucleus transcriptomic atlas of bovine placentation reveals dynamic cellular hierarchies and regulatory programs.Genome biology · 2026Article
- Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells.Communications biology · 2026Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 4 institutions in 4 countries.
Anna Arutyunyan *Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0003-0453-5443
Kenny Roberts *Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6155-0821
Kevin Troulé *Wellcome Sanger Institute, Cambridge, UK.
Frederick C K Wong *Wellcome Sanger Institute, Cambridge, UK.
Megan A Sheridan *Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-6878-7976
Ilia KatsDivision of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5220-5671
Luz Garcia-AlonsoWellcome Sanger Institute, Cambridge, UK.
Britta VeltenWellcome Sanger Institute, Cambridge, UK.
Regina HooWellcome Sanger Institute, Cambridge, UK.
Elias R Ruiz-MoralesWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5801-6190
Carmen Sancho-SerraWellcome Sanger Institute, Cambridge, UK.
Jarrod ShiltsWellcome Sanger Institute, Cambridge, UK.
Louis-Francois HandfieldWellcome Sanger Institute, Cambridge, UK.
Luca MarconatoDivision of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-3198-1326
Elizabeth TuckWellcome Sanger Institute, Cambridge, UK.
Lucy GardnerCentre for Trophoblast Research, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1735-2005
Cecilia Icoresi MazzeoWellcome Sanger Institute, Cambridge, UK.
Qian LiCentre for Trophoblast Research, University of Cambridge, Cambridge, UK.
Iva KelavaWellcome Sanger Institute, Cambridge, UK.
Gavin J WrightDepartment of Biology, Hull York Medical School, York Biomedical Research Institute, University of York, York, UK.ORCID http://orcid.org/0000-0003-0537-0863
Elena PrigmoreWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-8870-0316
Sarah A TeichmannWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-6294-6366
Omer Ali BayraktarWellcome Sanger Institute, Cambridge, UK. ob5@sanger.ac.uk.ORCID http://orcid.org/0000-0001-6055-277X
Ashley MoffettCentre for Trophoblast Research, University of Cambridge, Cambridge, UK. am485@cam.ac.uk.ORCID http://orcid.org/0000-0002-8388-9073
Oliver StegleWellcome Sanger Institute, Cambridge, UK. oliver.stegle@embl.de.ORCID http://orcid.org/0000-0002-8818-7193
Margherita Y TurcoCentre for Trophoblast Research, University of Cambridge, Cambridge, UK. margherita.turco@fmi.ch.ORCID http://orcid.org/0000-0002-3380-7375
Roser Vento-TormoWellcome Sanger Institute, Cambridge, UK. rv4@sanger.ac.uk.ORCID http://orcid.org/0000-0002-9870-8474
Wellcome Sanger Institute · GBUniversity of Cambridge · GBGerman Cancer Research Center · DEUniversity of York · GB
Funding
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7MMedical Research Council MR/S036350/1NICHD NIH HHS P50 HD103573Wellcome Trust
Abstract
The relationship between the human placenta-the extraembryonic organ made by the fetus, and the decidua-the mucosal layer of the uterus, is essential to nurture and protect the fetus during pregnancy. Extravillous trophoblast cells (EVTs) derived from placental villi infiltrate the decidua, transforming the maternal arteries into high-conductance vessels
Indexed as
MultiomicsPregnancy Trimester, FirstTrophoblastsCell CommunicationCell DifferentiationCell MovementDeciduaFemaleHumansMaternal-Fetal RelationsMyometriumOrganoidsPlacentaPregnancySingle-Cell AnalysisStem CellsTranscription Factors
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.