Evidence map›Paper›PMID 36991122›Full record

ArticleNature2023

Structural basis for GSDMB pore formation and its targeting by IpaH7.8.

Chengliang Wang, Sonia Shivcharan, Tian Tian, Skylar Wright, Danyang Ma, JengYih Chang, Kunpeng Li, Kangkang Song, Chen Xu, Vijay A Rathinam and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 85 citations in OpenAlex.

  1. The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Structural basis of GSDME pore formation and its regulation by S-palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Targeting of ELMO2 by thebioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Regulated cell death programs shaping cancer therapy.Cellular oncology (Dordrecht, Netherlands) · 2026
    Review
  12. ThebioRxiv : the preprint server for biology · 2026
    Article
  13. Pyroptosis: Turning Up the Heat on Cancer.Annual review of immunology · 2026
    Review
  14. NLRP1B is an integrated decoy that subvertsProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. A membrane insertion code for intrinsically disordered proteins.bioRxiv : the preprint server for biology · 2026
    Article
  17. Review
  18. Review
  19. Review
  20. Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Chengliang WangDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Sonia Shivcharan *Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Tian Tian *Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Skylar Wright *Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-1341-5710
Danyang MaDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
JengYih ChangDepartment of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Kunpeng LiCryo-Electron Microscopy Core, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Kangkang SongDepartment of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Chen XuDepartment of Biochemistry & Molecular Biotechnology and Cryo-Electron Microscopy Core Facility, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Vijay A RathinamDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA.ORCID http://orcid.org/0000-0002-8009-3977
Jianbin RuanDepartment of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT, USA. ruan@uchc.edu.ORCID http://orcid.org/0000-0001-5843-8273
UConn Health · USUniversity of Massachusetts Chan Medical School · USUniversity School · US

Funding

Cytosolic Immune Surveillance During Bacterial InfectionsR01AI119015 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RATHINAM, VIJAY · 2016 to 2025
$4.0M
New roles of IFN-inducible OAS proteins in innate immune defense against bacterial infectionsR01AI176333 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Vijay Rathinam, Saumendra N Sarkar · 2023 to 2026
$2.5M
Structural and mechanistic elucidation of non-canonical inflammasome signalingR01AI158435 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI RUAN, JIANBIN · 2021 to 2025
$2.0M
NIAID NIH HHS R01 AI119015NIAID NIH HHS R01 AI158435NIAID NIH HHS R01 AI176333
6 · The paper itself

Abstract

Gasdermins (GSDMs) are pore-forming proteins that play critical roles in host defence through pyroptosis

Indexed as

Bacterial ProteinsGasderminsPore Forming Cytotoxic ProteinsAnimalsBinding SitesConserved SequenceCryoelectron MicroscopyHumansMiceProtein DomainsProtein IsoformsPyroptosisShigellaSpecies SpecificityUbiquitin-Protein LigasesBacterial ProteinsGasderminsGSDMB protein, humanIpaH7.8 protein, Shigella flexneriPore Forming Cytotoxic ProteinsProtein IsoformsUbiquitin-Protein Ligases

Identifiers

PMID36991122
PMCPMC10115629
OpenAlexW4361291082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.