ArticleNPJ digital medicine2023
High night-to-night variability in sleep apnea severity is associated with uncontrolled hypertension.
Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 46 citations in OpenAlex.
- Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial.Nature medicine · 2026Trial
- Night-To-Night Variability in Sleep Apnea Is Associated With Persistence and Burden of Device-Detected Atrial Fibrillation.Journal of sleep research · 2026Article
- Wearable Devices for Monitoring and Management of Comorbid Obstructive Sleep Apnea and Hypertension: Scoping Review.JMIR mHealth and uHealth · 2026Article
- New Obstructive Sleep Apnoea Multi-Night Diagnostic Devices. Is a Single Night of Measurement Now Considered Enough?Respirology (Carlton, Vic.) · 2026Article
- Zero burden multi night monitoring with AI enabled technology reduces obstructive sleep apnea misdiagnosis.NPJ digital medicine · 2026Article
- Article
- Obstructive Sleep Apneas and Cardiovascular Diseases.Clocks & sleep · 2026Review
- Intermediate- and Long-Term Exposure to PMToxics · 2026Article
- Sleep apnoea and its consequences: from animal models to precision medicine.Sleep medicine · 2026Review
- Multi night digital assessment of sleep disordered breathing is associated with accelerated vascular aging.NPJ digital medicine · 2026Article
- Clinical Validation of Artificial Intelligence Algorithms for the Diagnosis of Adult Obstructive Sleep Apnea and Sleep Staging From Oximetry and Photoplethysmography-SleepAI.Journal of sleep research · 2026Article
- Review
- Digital Biometrics in Predicting Risk for Obstructive Sleep Apnea and Hypertension: Decentralized, Prospective Cohort Study.Journal of medical Internet research · 2025Article
- Characterisation of nocturnal arrhythmia avalanche dynamics: Insights from generalised linear model analysis.Journal of sleep research · 2025Article
- Research Priorities for Translating Endophenotyping of Adult Obstructive Sleep Apnea to the Clinic: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2025Article
- Objective sleep monitoring at home in older adults: A scoping review.Journal of sleep research · 2025Article
- Obstructive sleep apnea severity varies by season and environmental influences such as ambient temperature.Communications medicine · 2025Article
- Global warming may increase the burden of obstructive sleep apnea.Nature communications · 2025Article
- Multistate Modeling for Determining Transition Probabilities in Sleep Apnea Severity Across Multiple Nights of Recording.CHEST pulmonary · 2025Article
- Diagnostic Modalities in Sleep Disordered Breathing: Current and Emerging Technology and Its Potential to Transform Diagnostics.Respirology (Carlton, Vic.) · 2025Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Obstructive sleep apnea (OSA) severity can vary markedly from night-to-night. However, the impact of night-to-night variability in OSA severity on key cardiovascular outcomes such as hypertension is unknown. Thus, the primary aim of this study is to determine the effects of night-to-night variability in OSA severity on hypertension likelihood. This study uses in-home monitoring of 15,526 adults with ~180 nights per participant with an under-mattress sleep sensor device, plus ~30 repeat blood pressure measures. OSA severity is defined from the mean estimated apnea-hypopnoea index (AHI) over the ~6-month recording period for each participant. Night-to-night variability in severity is determined from the standard deviation of the estimated AHI across recording nights. Uncontrolled hypertension is defined as mean systolic blood pressure ≥140 mmHg and/or mean diastolic blood pressure ≥90 mmHg. Regression analyses are performed adjusted for age, sex, and body mass index. A total of 12,287 participants (12% female) are included in the analyses. Participants in the highest night-to-night variability quartile within each OSA severity category, have a 50-70% increase in uncontrolled hypertension likelihood versus the lowest variability quartile, independent of OSA severity. This study demonstrates that high night-to-night variability in OSA severity is a predictor of uncontrolled hypertension, independent of OSA severity. These findings have important implications for the identification of which OSA patients are most at risk of cardiovascular harm.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.