Evidence map›Paper›PMID 36991099›Full record

ArticleScientific reports2023

Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.

Hidetoshi Sumimoto, Atsushi Takano, Tomoyuki Igarashi, Jun Hanaoka, Koji Teramoto, Yataro Daigo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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  5. EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hidetoshi SumimotoDepartment of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Atsushi TakanoDepartment of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Tomoyuki IgarashiDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Jun HanaokaDepartment of Surgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Koji TeramotoDepartment of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Yataro DaigoDepartment of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Shiga, Japan. ydaigo@ims.u-tokyo.ac.jp.
Shiga University of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR)-mutated (mt) lung adenocarcinoma (LA) is refractory to immune checkpoint inhibitors (ICIs). However, the mechanisms have not been fully elucidated. CD8

Indexed as

Adenocarcinoma of LungLung NeoplasmsCell Line, TumorChromatinDrug Resistance, NeoplasmErbB ReceptorsGene ExpressionHistone Deacetylase InhibitorsHistonesHumansMutationProtein Kinase InhibitorsTumor MicroenvironmentChromatinErbB ReceptorsHistone Deacetylase InhibitorsHistonesProtein Kinase Inhibitors

Identifiers

PMID36991099
PMCPMC10060241
OpenAlexW4361301846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.