Evidence map›Paper›PMID 36991077›Full record

ArticleNPJ digital medicine2023

An adversarial training framework for mitigating algorithmic biases in clinical machine learning.

Jenny Yang, Andrew A S Soltan, David W Eyre, Yang Yang, David A Clifton

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Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jenny YangInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, England. jenny.yang@eng.ox.ac.uk.ORCID http://orcid.org/0000-0003-0352-8452
Andrew A S SoltanJohn Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, England.ORCID http://orcid.org/0000-0003-2391-5361
David W EyreBig Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, England.ORCID http://orcid.org/0000-0001-5095-6367
Yang YangSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
David A CliftonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, England.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Machine learning is becoming increasingly prominent in healthcare. Although its benefits are clear, growing attention is being given to how these tools may exacerbate existing biases and disparities. In this study, we introduce an adversarial training framework that is capable of mitigating biases that may have been acquired through data collection. We demonstrate this proposed framework on the real-world task of rapidly predicting COVID-19, and focus on mitigating site-specific (hospital) and demographic (ethnicity) biases. Using the statistical definition of equalized odds, we show that adversarial training improves outcome fairness, while still achieving clinically-effective screening performances (negative predictive values >0.98). We compare our method to previous benchmarks, and perform prospective and external validation across four independent hospital cohorts. Our method can be generalized to any outcomes, models, and definitions of fairness.

Identifiers

PMID36991077
PMCPMC10050816

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.