Evidence map›Paper›PMID 36990952›Full record

ReviewTrends in neurosciences2023

Crossmodal plasticity in hearing loss.

Andrej Kral, Anu Sharma

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Hearing aids for mild to moderate hearing loss in adults.The Cochrane database of systematic reviews · 2026
    Pooled it
  2. Pooled it
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  12. Dynamic functional connectivity following cochlear implantation: Predicting speech outcomes and exploring brain network dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  14. Review
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  20. Cross-modal functional plasticity after cochlear implantation.Cerebral cortex (New York, N.Y. : 1991) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrej KralInstitute of AudioNeuroTechnology and Department of Experimental Otology, Otolaryngology Clinics, Hannover Medical School, Hannover, Germany; Australian Hearing Hub, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
Anu SharmaDepartment of Speech Language and Hearing Science, Center for Neuroscience, Institute of Cognitive Science, University of Colorado Boulder, Boulder, CO, USA. Electronic address: anu.sharma@colorado.edu.

Funding

Effectiveness of Therapy via Telemedicine following Cochlear ImplantsU01DC013529 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI GRIGSBY, JAMES P, SHARMA, ANU · 2013 to 2017
$4.1M
Central Auditory Development in Hearing Impaired InfantsR01DC006257 · NIDCD · UNIVERSITY OF TEXAS DALLAS · PI SHARMA, ANU · 2004 to 2009
$2.6M
Neurocognitive Plasticity in Young Deaf Adults: Effects of Cochlear Implantation and Sign Language ExposureR01DC016346 · NIDCD · ROCHESTER INSTITUTE OF TECHNOLOGY · PI DYE, MATTHEW WILLIAM GEOFFREY, SHARMA, ANU · 2017 to 2021
$2.6M
NIDCD NIH HHS R01 DC006257NIDCD NIH HHS R01 DC016346NIDCD NIH HHS U01 DC013529
6 · The paper itself

Abstract

Crossmodal plasticity is a textbook example of the ability of the brain to reorganize based on use. We review evidence from the auditory system showing that such reorganization has significant limits, is dependent on pre-existing circuitry and top-down interactions, and that extensive reorganization is often absent. We argue that the evidence does not support the hypothesis that crossmodal reorganization is responsible for closing critical periods in deafness, and crossmodal plasticity instead represents a neuronal process that is dynamically adaptable. We evaluate the evidence for crossmodal changes in both developmental and adult-onset deafness, which start as early as mild-moderate hearing loss and show reversibility when hearing is restored. Finally, crossmodal plasticity does not appear to affect the neuronal preconditions for successful hearing restoration. Given its dynamic and versatile nature, we describe how this plasticity can be exploited for improving clinical outcomes after neurosensory restoration.

Indexed as

Auditory CortexDeafnessHearing LossAcoustic StimulationAdultHumansNeuronal PlasticityPhotic Stimulationcochlear implantsconnectivitydeafnesshearing aidsmultisensoryoscillations

Identifiers

PMID36990952
PMCPMC10121905

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.