Evidence map›Paper›PMID 36990867›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2023

Early United States experience with lung donation after circulatory death using thoracoabdominal normothermic regional perfusion.

Alice L Zhou, Jessica M Ruck, Alfred J Casillan, Emily L Larson, Benjamin L Shou, Alexander K Karius, Jinny S Ha, Pali D Shah, Christian A Merlo, Errol L Bush

Abstract read
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Lung Transplantation in Controlled Donation after Circulatory-Determination-of-Death Using Normothermic Abdominal Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alice L ZhouDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Jessica M RuckDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Alfred J CasillanDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Emily L LarsonDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Benjamin L ShouDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Alexander K KariusDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Jinny S HaDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland.
Pali D ShahPulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
Christian A MerloPulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
Errol L BushDivision of Thoracic Surgery, Department of Surgery, Johns Hopkins Hospital, Baltimore, Maryland. Electronic address: errol.bush@jhu.edu.

Funding

Frailty and post-liver transplant delirium and cognitive impairment in older recipientsF32AG067642 · NIA · JOHNS HOPKINS UNIVERSITY · PI RUCK, JESSICA MOORE · 2021 to 2023
$258k
NIA NIH HHS F32 AG067642
6 · The paper itself

Abstract

Thoracoabdominal normothermic regional perfusion (TA-NRP) has recently begun being utilized in the United States for recovery of cardiothoracic allografts from some donors after circulatory death (DCD), but data on lungs recovered in this method is limited to case reports. We conducted a national retrospective review of lung transplants from DCD donors recovered using TA-NRP. Of the 434 total DCD lung transplants performed between January 2020 and March 2022, 17 were recovered using TA-NRP. Compared to direct recovery DCD transplants, recipients of TA-NRP DCD transplants had lower likelihood of ventilation >48 hours (23.5% vs 51.3%, p = 0.027) and similar likelihood of predischarge acute rejection, requirement for extracorporeal membrane oxygenation at 72 hours, hospital lengths of stay, and survival at 30, 60, and 90 days post-transplant. These early data suggest that DCD lung recovery using TA-NRP might be a safe way to further expand the donor pool and warrant further study.

Indexed as

Extracorporeal Membrane OxygenationTissue and Organ ProcurementDeathGraft SurvivalHumansLungOrgan PreservationPerfusionRetrospective StudiesTissue Donorsdonation after circulatory deathlung transplantationnormothermic regional perfusionoutcomes

Identifiers

PMID36990867
PMCPMC10192114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.