Evidence map›Paper›PMID 36990723›Full record

ArticleNeurology2023

Pearls & Oy-sters: Hemorrhagic Myelitis Following SARS-CoV-2 Infection.

Karlo Toljan, Ahmad Mahadeen, Moein Amin, Mary Rensel, Stephen E Jones, Daniel Ontaneda, Amy C Kunchok

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Karlo ToljanFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.ORCID 0000-0002-3189-9659
Ahmad MahadeenFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.
Moein AminFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.ORCID 0000-0002-9587-0644
Mary RenselFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.ORCID 0000-0001-9613-8394
Stephen E JonesFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.
Daniel OntanedaFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH.ORCID 0000-0002-2838-9148
Amy C KunchokFrom the Department of Neurology (K.T., M.A.), and Mellen Center for Multiple Sclerosis Treatment and Research (A.M., M.R., D.O., A.C.K.), Neurological Institute, and Section of Neuroradiology (S.E.J.), Imaging Institute, Cleveland Clinic, OH. kunchoa@ccf.org.
The Neurological Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemorrhage in the setting of myelitis is rarely seen in clinical practice. We report a series of 3 women aged 26, 43, and 44 years, who presented with acute hemorrhagic myelitis within 4 weeks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Two required intensive care, and 1 had severe disease with multiorgan failure. Serial MRI of the spine demonstrated T2-weighted hyperintensity with T1-weighted postcontrast enhancement in the medulla and cervical spine (patient 1) and thoracic spine (patients 2 and 3). Hemorrhage was identified on precontrast T1-weighted, susceptibility-weighted, and gradient echo sequences. Distinct from typical inflammatory or demyelinating myelitis, clinical recovery was poor in all cases, with residual quadriplegia or paraplegia, despite immunosuppression. These cases highlight that although hemorrhagic myelitis is rare, it can occur as a post/parainfectious complication of SARS-CoV-2 infection.

Indexed as

COVID-19MyelitisFemaleHemorrhageHumansMagnetic Resonance ImagingSARS-CoV-2

Identifiers

PMID36990723
PMCPMC10424833
OpenAlexW4361294991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.