Evidence map›Paper›PMID 36990469›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Differential neural processing of value during decision-making in adults with attention-deficit/hyperactivity disorder and healthy controls.

Chun-Yi Lee, Joshua Oon Soo Goh, Susan Shur-Fen Gau

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02642068 (Neuropsychology, Neuroimage and Neurophysiology in Adults With Attention-Deficit Hyperactivity Disorder), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02642068 completednot on this map

Neuropsychology, Neuroimage and Neurophysiology in Adults With Attention-Deficit Hyperactivity Disorder: An Endophenotype and Follow-up Study

TypeobservationalSponsorNational Taiwan University HospitalRan2014 to 2019Enrolled300ConditionsAttention Deficit Hyperactivity Disorder
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Chun-Yi LeeFrom the Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan (Lee, Goh, Gau); the Department of Psychology, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Neurobiological and Cognitive Science Center, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Artificial Intelligence and Robotics Center, National Taiwan University, Taipei, Taiwan (Goh); the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Gau).
Joshua Oon Soo GohFrom the Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan (Lee, Goh, Gau); the Department of Psychology, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Neurobiological and Cognitive Science Center, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Artificial Intelligence and Robotics Center, National Taiwan University, Taipei, Taiwan (Goh); the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Gau) joshuagoh@ntu.edu.tw gaushufe@ntu.edu.tw.
Susan Shur-Fen GauFrom the Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei, Taiwan (Lee, Goh, Gau); the Department of Psychology, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Neurobiological and Cognitive Science Center, National Taiwan University, Taipei, Taiwan (Goh, Gau); the Artificial Intelligence and Robotics Center, National Taiwan University, Taipei, Taiwan (Goh); the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan (Gau) joshuagoh@ntu.edu.tw gaushufe@ntu.edu.tw.
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Influence of Culture on Learning and Decision Making with AgeR01AG061886 · NIA · BRANDEIS UNIVERSITY · PI GOH, JOSHUA, GUTCHESS, ANGELA · 2019 to 2023
$2.2M
NIA NIH HHS R01 AG061886
6 · The paper itself

Abstract

backgroundRisk-taking behaviours are observed among adults with attention-deficit/hyperactivity disorder (ADHD). We sought to evaluate altered neural processing of stimuli values associated with risk-taking decision behaviour, distinct from learning requirements, among adults with ADHD.

methodsOverall, 32 adults with ADHD and 32 healthy controls without ADHD underwent a lottery choice task in a functional magnetic resonance imaging (fMRI) experiment. Participants accepted or rejected stakes with explicit information about variable probabilities of winning or losing points at different magnitudes. Outcomes were independent across trials, circumventing reward learning. Data analysis explored group differences in neurobehavioural responses to stimuli values during choice decision-making processing and outcome feedback.

resultsCompared with healthy controls, adults with ADHD had slower response times and tended to accept more stakes with a middle-to-low probability of winning. Adults with ADHD had evidence of lower dorsolateral prefrontal cortex (DLPFC) activity and reduced sensitivity in the ventromedial prefrontal cortex (VMPFC) region of interest in response to linear changes in probability, compared with healthy controls. Lower DLPFC responses were associated with lower VMPFC probability sensitivity and greater risk-taking among healthy controls but not adults with ADHD. Compared with health controls, adults with ADHD showed higher responses to loss outcomes in the putamen and hippocampus. LIMITATIONS: Assessments of real-life decision behaviours are required to further validate the experimental findings.

conclusionsOur findings explore tonic and phasic neural processing of value-related information that modulates risk-taking behaviours among adults with ADHD. Dysregulated neural computation of the values of behavioural actions and outcomes in the frontostriatal circuits may underlie decision processing distinct from reward learning differences among adults with ADHD. CLINICAL

trial registrationNCT02642068.

Indexed as

Attention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexHumansLearningMagnetic Resonance ImagingPrefrontal CortexReward

Identifiers

PMID36990469
PMCPMC10065803
OpenAlexW4361287302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.