Evidence map›Paper›PMID 36990370›Full record

ReviewNeuroscience and biobehavioral reviews2023

Consensus design of a calibration experiment for human fear conditioning.

Dominik R Bach, Juliana Sporrer, Rany Abend, Tom Beckers, Joseph E Dunsmoor, Miquel A Fullana, Matthias Gamer, Dylan G Gee, Alfons Hamm, Catherine A Hartley and 14 more

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Adaptive suppression of threat-history stimuli.Attention, perception & psychophysics · 2025
    Article
  7. Article
  8. Fear extinction retention in children, adolescents, and adults.Developmental cognitive neuroscience · 2025
    Article
  9. An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Adaptive thresholding increases sensitivity to detect changes in the rate of skin conductance responses to psychologically arousing stimuli in both laboratory and ambulatory settings.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024
    Article
  16. Exercise and Fear and Safety Learning.Current topics in behavioral neurosciences · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Dominik R BachWellcome Centre for Human Neuroimaging and Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, United Kingdom; Hertz Chair for Artificial Intelligence and Neuroscience, Transdisciplinary Research Area "Life & Health", University of Bonn, Germany. Electronic address: d.bach@uni-bonn.de.
Juliana SporrerWellcome Centre for Human Neuroimaging and Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, United Kingdom.
Rany AbendNational Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.
Tom BeckersKU Leuven, Faculty of Psychology and Educational Sciences/Leuven Brain Institute, Leuven, Belgium.
Joseph E DunsmoorDepartment of Psychiatry and Behavioral Sciences, University of Texas at Austin, USA.
Miquel A FullanaInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, & Adult Psychiatry and Psychology Department, Institute of Neurosciences, Hospital Clínic, Barcelona, Spain.
Matthias GamerJulius-Maximilians-University of Würzburg, Department of Psychology, Würzburg, Germany.
Dylan G GeeYale University, Department of Psychology, New Haven, CT, USA.
Alfons HammDepartment of Psychology, University of Greifswald, Germany.
Catherine A HartleyNew York University, Department of Psychology, New York, NY, USA.
Ryan J HerringaDepartment of Psychiatry, University of Wisconsin School of Medicine & Public Health, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Raffael KalischNeuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany; and Leibniz Institute for Resilience Research (LIR), Mainz, Germany.
David C KnightUniversity of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
Shmuel LissekClinical Science and Psychopathology Research Program, Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Tina B LonsdorfUniversity Medical Center Hamburg-Eppendorf, Institute of Systems Neuroscience, Hamburg, Germany.
Christian J MerzRuhr University Bochum, Faculty of Psychology, Institute of Cognitive Neuroscience, Department of Cognitive Psychology, Bochum, Germany.
Mohammed MiladDepartment of Psychiatry and Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA; The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Jayne MorrissSchool of Psychology and Clinical Language Sciences, University of Reading, United Kingdom.
Elizabeth A PhelpsDepartment of Psychology, Harvard University, 52 Oxford St., Cambridge, MA, USA.
Daniel S PineNational Institute of Mental Health Intramural Research Program, Bethesda, MD, USA.
Andreas OlssonKarolinska Institutet, Department of Clinical Neuroscience, Division of Psychology, Stockholm, Sweden.
Carien M van ReekumSchool of Psychology and Clinical Language Sciences, University of Reading, United Kingdom.
Daniela SchillerFriedman Brain Institute, Department of Neuroscience, Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Neurocomputational mechanisms of proactive social behavior deficits in autism spectrum disorderR01MH122611 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FOSS-FEIG, JENNIFER, GU, XIAOSI · 2020 to 2024
$3.9M
Neural, computational and behavioral characterization of dynamic social behavior in borderline and avoidant personality disorderR01MH123069 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GU, XIAOSI, KOENIGSBERG, HAROLD W · 2021 to 2025
$3.1M
Impact of Trauma Exposure on Critical Periods in Brain Development and Fear Processing in ChildrenR01MH111682 · NIMH · WAYNE STATE UNIVERSITY · PI JOVANOVIC, TANJA · 2016 to 2020
$3.0M
Department of HealthIntramural NIH HHS ZIA MH002781NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH111682NIMH NIH HHS R01 MH122611NIMH NIH HHS R01 MH123069Wellcome Trust 203147/Z/16/Z
6 · The paper itself

Abstract

Fear conditioning is a widely used laboratory model to investigate learning, memory, and psychopathology across species. The quantification of learning in this paradigm is heterogeneous in humans and psychometric properties of different quantification methods can be difficult to establish. To overcome this obstacle, calibration is a standard metrological procedure in which well-defined values of a latent variable are generated in an established experimental paradigm. These intended values then serve as validity criterion to rank methods. Here, we develop a calibration protocol for human fear conditioning. Based on a literature review, series of workshops, and survey of N = 96 experts, we propose a calibration experiment and settings for 25 design variables to calibrate the measurement of fear conditioning. Design variables were chosen to be as theory-free as possible and allow wide applicability in different experimental contexts. Besides establishing a specific calibration procedure, the general calibration process we outline may serve as a blueprint for calibration efforts in other subfields of behavioral neuroscience that need measurement refinement.

Indexed as

FearLearningCalibrationConsensus Statements as TopicHumansCalibration designExperimental designExperiment-based calibrationHuman fear conditioningMeasurement theoryMetrologyMulti-laboratory consensus

Identifiers

PMID36990370
PMCPMC10618407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.