Evidence map›Paper›PMID 36990366›Full record

ArticleNeurobiology of disease2023

The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome.

Ruth Westenbroek, Joshua Kaplan, Katie Viray, Nephi Stella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Dravet syndrome: novel insights intoFrontiers in neuroscience · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ruth WestenbroekDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Joshua KaplanDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Psychology, Western Washington University, Bellingham, WA 98225, USA.
Katie VirayDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Nephi StellaDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: nstella@uw.edu.
University of Washington · USWestern Washington University · US

Funding

Molecular mechanism of ABHD6 enzymatic activity in neuronsR21NS118130 · NINDS · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2020 to 2020
$428k
Anti-Epileptic Action of ABHD6 Inhibitors as Treatment for Dravet SyndromeR21NS098777 · NINDS · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2017 to 2018
$427k
NINDS NIH HHS R21 NS098777NINDS NIH HHS R21 NS118130
6 · The paper itself

Abstract

Evidence suggests that inhibition of α/β hydrolase-domain containing 6 (ABHD6) reduces seizures; however, the molecular mechanism of this therapeutic response remains unknown. We discovered that heterozygous expression of Abhd6 (Abhd6

Indexed as

Epilepsies, MyoclonicAnimalsgamma-Aminobutyric AcidHydrolasesMiceMonoacylglycerol LipasesNAV1.1 Voltage-Gated Sodium ChannelNeuronsSerineABHD6 protein, mousegamma-Aminobutyric AcidHydrolasesMonoacylglycerol LipasesNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mouseSerineDravet syndromeEpilepsyGABA receptorsSeizures

Identifiers

PMID36990366
PMCPMC10332637
OpenAlexW4360999390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.