ReviewNeurobiology of disease2023
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets.
Review in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 66 citations in OpenAlex.
- Disrupted thalamic functional hierarchy on resting-state fMRI in idiopathic generalized epilepsy.European radiology experimental · 2026Article
- Volumetric and functional connectivity alterations of the thalamus and thalamic nuclei groups in drug-resistant focal epilepsy: A 7T MRI study.Neuroradiology · 2026Article
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Convulsive-Like Movements in Posterior Circulation Large Vessel Occlusion: Associations With Midbrain Injury and Poor Outcome.CNS neuroscience & therapeutics · 2026Article
- Beyond seizure control: Identifying deficits in cognitive networks in absence epilepsy.Science advances · 2026Article
- Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy.Molecular psychiatry · 2026Article
- Connectivity between the seizure onset zone and the thalamus correlates with seizure outcomes in thalamic responsive neurostimulation.Epilepsia · 2026Article
- Trigeminal neuralgia-like pain in a vagus nerve stimulationEpilepsy & behavior reports · 2026Article
- 3D printed pediatric head phantom for assessing deep epileptic sources localization.Computers in biology and medicine · 2026Article
- Unraveling Lennox-Gastaut Syndrome: From Molecular Pathogenesis to Precision Diagnosis and Targeted Therapy Evolving Therapeutic Strategies.International journal of molecular sciences · 2026Review
- Corticothalamic dynamics during postictal recovery of self-orientation after electroconvulsive therapy.Brain communications · 2026Article
- The potential of laminar functional MRI in refining the understanding of epilepsy in humans.Brain : a journal of neurology · 2025Review
- Absence seizures and sleep-wake abnormalities in a rat model of GRIN2B neurodevelopmental disorder.Epilepsia · 2025Article
- Noninvasive Biomarkers for Assessing the Excitatory/Inhibitory Imbalance in Children with Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Synchronized Hypsarrhythmia as a Potential EEG Signature in Genetic Infantile Epileptic Spasms Syndrome: Is there a Gene Network Association?Indian journal of pediatrics · 2025Article
- Short-Term Modulation of Epileptic Network with Low-Frequency Thalamic Stimulation.medRxiv : the preprint server for health sciences · 2025Article
- High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.Neurobiology of disease · 2025Article
- Enhanced response inhibition in patients with drug-resistant juvenile myoclonic epilepsy: Event-related potentials evidence of excitatory-inhibitory imbalance.Epilepsia open · 2025Article
- Prognostic Values of Thalamic Metabolic Abnormalities in Children with Epilepsy.Diagnostics (Basel, Switzerland) · 2025Article
- Impairment of Spatial Working Memory but Preservation of Recognition Memory in Female Rats with Spontaneous Absence Seizures.Neurochemical research · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Generalized epilepsy affects 24 million people globally; at least 25% of cases remain medically refractory. The thalamus, with widespread connections throughout the brain, plays a critical role in generalized epilepsy. The intrinsic properties of thalamic neurons and the synaptic connections between populations of neurons in the nucleus reticularis thalami and thalamocortical relay nuclei help generate different firing patterns that influence brain states. In particular, transitions from tonic firing to highly synchronized burst firing mode in thalamic neurons can cause seizures that rapidly generalize and cause altered awareness and unconsciousness. Here, we review the most recent advances in our understanding of how thalamic activity is regulated and discuss the gaps in our understanding of the mechanisms of generalized epilepsy syndromes. Elucidating the role of the thalamus in generalized epilepsy syndromes may lead to new opportunities to better treat pharmaco-resistant generalized epilepsy by thalamic modulation and dietary therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.