ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2023
Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- EEG CONNECT: A proposed reporting checklist for EEG-based connectivity studies in clinical epilepsy research.Epilepsia open · 2026Review
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Perioperative Management of Pediatric Epilepsy Neuromodulation Devices.Children (Basel, Switzerland) · 2026Review
- Article
- Focused ultrasound suppresses pentylenetetrazol-induced epileptiform activity in rats and alters connectivity measured by functional MRI.Scientific reports · 2025Article
- Visualization of functional and effective connectivity underlying auditory descriptive naming.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Normative high-frequency oscillation phase-amplitude coupling and effective connectivity under sevoflurane.Brain communications · 2025Article
- Normative atlases of high-frequency oscillation and spike rates under Sevoflurane anesthesia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Deep Learning for Epileptic Seizure Detection Using a Causal-Spatio-Temporal Model Based on Transfer Entropy.Entropy (Basel, Switzerland) · 2024Article
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12 authors.
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Abstract
objectiveTo determine how sevoflurane anesthesia modulates intraoperative epilepsy biomarkers on electrocorticography, including high-frequency oscillation (HFO) effective connectivity (EC), and to investigate their relation to epileptogenicity and anatomical white matter.
methodsWe studied eight pediatric drug-resistant focal epilepsy patients who achieved seizure control after invasive monitoring and resective surgery. We visualized spatial distributions of the electrocorticography biomarkers at an oxygen baseline, three time-points while sevoflurane was increasing, and at a plateau of 2 minimum alveolar concentration (MAC) sevoflurane. HFO EC was combined with diffusion-weighted imaging, in dynamic tractography.
resultsIntraoperative HFO EC diffusely increased as a function of sevoflurane concentration, although most in epileptogenic sites (defined as those included in the resection); their ability to classify epileptogenicity was optimized at sevoflurane 2 MAC. HFO EC could be visualized on major white matter tracts, as a function of sevoflurane level.
conclusionsThe results strengthened the hypothesis that sevoflurane-activated HFO biomarkers may help intraoperatively localize the epileptogenic zone. SIGNIFICANCE: Our results help characterize how HFOs at non-epileptogenic and epileptogenic networks respond to sevoflurane. It may be warranted to establish a normative HFO atlas incorporating the modifying effects of sevoflurane and major white matter pathways, as critical reference in epilepsy presurgical evaluation.
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