Evidence map›Paper›PMID 36989587›Full record

ArticleJournal of the neurological sciences2023

Altered visual conscious awareness in patients with vestibular dysfunctions; a cross-sectional observation study.

Mishaal Sharif, Yougan Saman, Rose Burling, Oliver Rea, Rakesh Patel, Douglas J K Barrett, Peter Rea, Amir Kheradmand, Qadeer Arshad

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Vestibular Dysfunction and Binocular Vision Impairment: A New Clinical Perspective.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  2. Review
  3. Focused Update on Migraine and Vertigo Comorbidity.Current pain and headache reports · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Mishaal SharifinAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK.
Yougan SamaninAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK; Balance Clinic, E.N.T Department, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
Rose BurlinginAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK.
Oliver ReainAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK.
Rakesh PatelFaculty of Health and Life Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
Douglas J K BarrettinAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK.
Peter ReaBalance Clinic, E.N.T Department, Leicester Royal Infirmary, Leicester LE1 5WW, UK.
Amir KheradmandDepartment of Neurology, The Johns Hopkins University, Baltimore, MD, USA; Department of Neuroscience, The Johns Hopkins University, Baltimore, MD, USA. Electronic address: akherad@jhu.edu.
Qadeer ArshadinAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester LE1 7RH, UK; Neuro-Otology Unit, Division of Brain Sciences, Charing Cross Hospital Campus, Imperial College London, Fulham Palace Road, London W6 8RF, UK. Electronic address: qa15@leicester.ac.uk.
University of Leicester · GBDe Montfort University · GBImperial College London · GBJohns Hopkins University · USLeicester Royal Infirmary · GB

Funding

Elucidating the neural mechanisms of spatial disorientation in vestibular migraineR01DC018815 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI KHERADMAND, AMIR · 2020 to 2024
$2.3M
NIDCD NIH HHS R01 DC018815
6 · The paper itself

Abstract

backgroundPatients with vestibular dysfunctions often experience visual-induced symptoms. Here we asked whether such visual dependence can be related to alterations in visual conscious awareness in these patients.

methodsTo measure visual conscious awareness, we used the effect of motion-induced blindness (MIB,) in which the perceptual awareness of the visual stimulus alternates despite its unchanged physical characteristics. In this phenomenon, a salient visual target spontaneously disappears and subsequently reappears from visual perception when presented against a moving visual background. The number of perceptual switches during the experience of the MIB stimulus was measured for 120 s in 15 healthy controls, 15 patients with vestibular migraine, 15 patients with benign positional paroxysmal vertigo (BPPV) and 15 with migraine without vestibular symptoms.

resultsPatients with vestibular dysfunctions (i.e., both vestibular migraine and BPPV) exhibited increased perceptual fluctuations during MIB compared to healthy controls and migraine patients without vertigo. In VM patients, those with more severe symptoms exhibited higher fluctuations of visual awareness (i.e., positive correlation), whereas, in BPPV patients, those with more severe symptoms had lower fluctuations of visual awareness (i.e., negative correlation). IMPLICATIONS: Taken together, these findings show that fluctuations of visual awareness are linked to the severity of visual-induced symptoms in patients with vestibular dysfunctions, and distinct pathophysiological mechanisms may mediate visual vertigo in peripheral versus central vestibular dysfunctions.

Indexed as

Benign Paroxysmal Positional VertigoMigraine DisordersCross-Sectional StudiesDizzinessHumansVisual PerceptionBPPVVestibular migraineVisual conscious awarenessVisual vertigo

Identifiers

PMID36989587
PMCPMC10112837
OpenAlexW4353094053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.