Evidence map›Paper›PMID 36989362›Full record

ArticleScience advances2023

A simple, time- and cost-effective, high-throughput depletion strategy for deep plasma proteomics.

Arthur Viode, Patrick van Zalm, Kinga K Smolen, Benoit Fatou, David Stevenson, Meenakshi Jha, Ofer Levy, Judith Steen, Hanno Steen, IMPACC Network

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arthur ViodeDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-3418-734X
Patrick van ZalmDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-0806-3685
Kinga K SmolenHarvard Medical School, Boston, MA, USA.ORCID 0000-0001-8650-3693
Benoit FatouDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-8650-3693
David StevensonDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.
Meenakshi JhaDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6093-871X
Ofer LevyHarvard Medical School, Boston, MA, USA.ORCID 0000-0002-5859-1945
Judith SteenDepartment of Neuropsychology and Psychopharmacology, EURON, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.ORCID 0000-0002-8167-0772
Hanno SteenDepartment of Pathology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-0179-6648
IMPACC Network

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
Translation of immunologic technologies from basic research into pre-clinical nonU19AI062629 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 2004 to 2023
$56.2M
Systems investigation of vaccine responses in B cell depleted autoimmune patientsU19AI089992 · NIAID · YALE UNIVERSITY · PI David A. Hafler, RUTH R MONTGOMERY · 2010 to 2026
$50.4M
Project 3 - Ex vivo immune profiling of dengue viruses and vaccinesU19AI118610 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KASARSKIS, ANDREW · 2015 to 2021
$46.6M
Systems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0M
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle · 2008 to 2026
$41.1M
Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7M
Tollip inhibits IL-33 signaling during airway influenza virus infectionU19AI125357 · NIAID · UNIVERSITY OF ARIZONA · PI KRAFT, MONICA, VERCELLI, DONATA · 2016 to 2025
$14.7M
Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LANIER, LEWIS LEE · 2017 to 2021
$11.2M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
The contribution of GPCRs to thymocyte medullary entry and central toleranceR01AI104870 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI Lauren Ilyse Richie EHRLICH · 2014 to 2026
$7.6M
Investigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination. U19AI128910 · NIAID · DREXEL UNIVERSITY · PI KALEEBU, PONTIANO · 2017 to 2021
$7.0M
NIAID NIH HHS R01 AI104870NIAID NIH HHS R01 AI135803NIAID NIH HHS R01 AI145835NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI062629NIAID NIH HHS U19 AI077439NIAID NIH HHS U19 AI089992NIAID NIH HHS U19 AI090023NIAID NIH HHS U19 AI118608NIAID NIH HHS U19 AI118610NIAID NIH HHS U19 AI125357NIAID NIH HHS U19 AI128910NIAID NIH HHS U19 AI128913NIAID NIH HHS U24 AI152179NIAID NIH HHS U54 AI142766NIA NIH HHS R01 AG071858NICHD NIH HHS P50 HD105351
6 · The paper itself

Abstract

We introduce a cost-effective, robust high-throughput-compatible plasma depletion method enabling in-depth profiling of plasma that detects >1300 proteins per run with a throughput of 60 samples per day. The method has been fully validated by processing >3000 samples with no apparent batch effect at a cost for the depletion step of ~$2.5 per sample.

Indexed as

ProteinsProteomicsCost-Benefit AnalysisProteins

Identifiers

PMID36989362
PMCPMC10058233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.