ArticleeLife2023
Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation.
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In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 35 citations in OpenAlex.
- Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions.Nucleus (Austin, Tex.) · 2026Review
- Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development.Nucleus (Austin, Tex.) · 2026Review
- Endothelial Nucleoporin93 (Nup93) Maintains Vascular Homeostasis via Sun1-Dependent Regulation of RhoA/ROCK Activity.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Mechanosensitive FHL2 tunes endothelial function via microtubule-actomyosin crosstalk.The EMBO journal · 2026Article
- Genomics in Equine MEED: Whole-Genome Sequencing and Target Mutation Identification.Animals : an open access journal from MDPI · 2026Article
- Nuclear SUN2 coordinates endothelial cell-matrix interactions to regulate blood vessel homeostasis and barrier function.bioRxiv : the preprint server for biology · 2026Article
- The inner nuclear membrane protein SUN1 regulates cullin-3 neddylation to maintain insulin signaling.bioRxiv : the preprint server for biology · 2026Article
- Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation.International journal of molecular sciences · 2026Review
- A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling.Research (Washington, D.C.) · 2026Article
- Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina.Communications biology · 2025Article
- Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease.Nucleus (Austin, Tex.) · 2025Review
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- Article
- Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis.APL bioengineering · 2025Review
- Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.Journal of inflammation research · 2025Article
- Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Mechanical signal-chromatin interactions: molecular networks from nuclear membrane force transmission to epigenetic regulation.Frontiers in medicine · 2025Review
- Differential endothelial cell cycle status in postnatal retinal vessels revealed using a novel PIP-FUCCI reporter and zonation analysis.Angiogenesis · 2024Article
- P300 Modulates Endothelial Mechanotransduction of Fluid Shear Stress.Cellular and molecular bioengineering · 2024Article
- Acetaminophen Overdose Reveals Protease-Activated Receptor 4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Danielle B BuglakCurriculum in Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-8702-4018
Pauline BougaranDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Molly R KulikauskasCurriculum in Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0001-5186-9740
Ziqing LiuDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Elizabeth Monaghan-BensonDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, United States.
Ariel L GoldDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Allison P MarvinDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Andrew BurciuDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Natalie T TankeCurriculum in Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Morgan OatleyDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0001-9465-6585
Shea N RickettsDepartment of Pathology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Karina KinghornCurriculum in Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Bryan N JohnsonDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Celia E ShiauDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Stephen RogersDepartment of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Christophe GuilluyDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, United States.
Victoria L BautchCurriculum in Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-2135-5153
University of North Carolina at Chapel Hill · USNorth Carolina State University · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MPre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7MMOLECULAR AND CELLULAR CONTROL OF ANGIOGENESISR35HL139950 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUTCH, VICTORIA L · 2018 to 2024
$6.4MNCI NIH HHS P30 CA016086NHLBI NIH HHS R35 HL139950NHLBI NIH HHS T32 HL069768NIH HHS 5T32HL069768-17NIH HHS R35 HL139950
Abstract
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions. The nucleus also regulates endothelial cell behaviors, but it is unclear how the nucleus contributes to endothelial cell activities at the cell periphery. Here, we show that the nuclear-localized
Indexed as
Endothelial CellsMicrotubule-Associated ProteinsAnimalsIntercellular JunctionsMiceMicrotubulesNuclear ProteinsZebrafishMicrotubule-Associated ProteinsNuclear ProteinsSUN1 protein, mouseadherens junctionsangiogenesisblood vesselscell biologycontractilityendothelial cellendothelial cellsGEF-H1microtubulesmouseNesprin-1nuclear LINC complexRhoSUN1zebrafish
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.