Evidence map›Paper›PMID 36989087›Full record

ArticleBiomacromolecules2023

Synthesis and Nuclear Magnetic Resonance Structural Evaluation of Oxime-Linked Oligosialic Acid-Based Glycodendrimers.

James P Cerney, Aleksey Raskovalov, Monica Nasseri, Madeline D Silva, Katherine D McReynolds

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James P CerneyDepartment of Chemistry, California State University, Sacramento 6000 J Street, Sacramento, California 95819-6057, United States.
Aleksey RaskovalovDepartment of Chemistry, California State University, Sacramento 6000 J Street, Sacramento, California 95819-6057, United States.
Monica NasseriDepartment of Chemistry, California State University, Sacramento 6000 J Street, Sacramento, California 95819-6057, United States.
Madeline D SilvaDepartment of Chemistry, California State University, Sacramento 6000 J Street, Sacramento, California 95819-6057, United States.
Katherine D McReynoldsDepartment of Chemistry, California State University, Sacramento 6000 J Street, Sacramento, California 95819-6057, United States.ORCID 0000-0001-8395-3066

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
15 Tesla Bruker solariX FTICR MSS10OD018507 · OD · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2014 to 2014
$2.0M
Glycopolymer Inhibitors of Heparan Sulfate Proteoglycan Binding PathogensSC3GM119521 · NIGMS · CALIFORNIA STATE UNIVERSITY SACRAMENTO · PI MCREYNOLDS, KATHERINE D · 2016 to 2024
$851k
NCI NIH HHS P30 CA016058NIH HHS S10 OD018507
6 · The paper itself

Abstract

A series of four oxime-linked octavalent sialic acid and oligosialic acid poly(ether amidoamine) glycodendrimers were synthesized. In the attachment of the sialic acids to the dendrimer core, chemoselective oxime bonds were formed between the unprotected sugars (sialic acid or α-2,8-linked di- through tetra-sialic acids) and the aminooxy-terminated dendrimer core in a microwave-mediated reaction, resulting in good to excellent yields (58-100%) of the fully functionalized octavalent glycodendrimers. Next, using a combination of 1D and 2D nuclear magnetic resonance and working from the inside outward, we employed a systematic method to assign the proton and carbon signals starting with the smallest linkers and dendrimer cores and moving gradually up to the completed octavalent glycodendrimers. Through this approach, the assignment of the protons and carbons was possible, including the

Indexed as

DendrimersN-Acetylneuraminic AcidMagnetic Resonance SpectroscopyOximesSialic AcidsDendrimersN-Acetylneuraminic AcidOximesSialic Acids

Identifiers

PMID36989087
PMCPMC10091409

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.