Evidence map›Paper›PMID 36988981›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2022

Serotonin Syndrome in an Infant Associated With Linezolid and Opioid Use.

Jenna Essakow, Lulu Jin, Neelima Marupudi, Rachel Wattier, Patrick McQuillen, Deborah Franzon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jenna EssakowDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Lulu JinDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Neelima MarupudiDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Rachel WattierDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Patrick McQuillenDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
Deborah FranzonDepartment of Pediatrics (JE, LJ, NM, RW, PM, DF), Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.
UCSF Benioff Children's Hospital · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most reported cases of serotonin syndrome involve either a selective serotonin reuptake inhibitor (SSRI) or monoamine oxidase inhibitors (MAOI) and at least 1 other serotonergic medication or exposure to a single serotonin-augmenting drug. This case report describes serotonin syndrome occurring in association with the concomitant use of the antibiotic linezolid and opioids, specifically methadone, in a pediatric intensive care unit patient. The patient developed hyperpyrexia, muscle rigidity, clonus, and multiorgan dysfunction within 48 hours of receiving linezolid while concurrently on methadone. This drug-drug interaction is a rare cause of serotonin syndrome that has only been described 1 other time in the adult literature. This report raises awareness of this rare but serious and potentially lethal complication of serotonin syndrome associated with concomitant linezolid and opioid use. Timely consideration of the diagnosis in the setting of hyperpyrexia can facilitate prompt initiation of targeted therapies to prevent sequela.

Indexed as

hyperpyrexialinezolidnosocomial pneumoniaopioidspediatricsserotonin syndrome

Identifiers

PMID36988981
PMCPMC9400179
OpenAlexW4292384615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.