ArticleACS chemical biology2023
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.
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Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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29citing papers in PubMed, 2 pooled it
13.2field-weighted citation impact, top 1% of its field
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Exercise prescription for axial spondyloarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Pooled it
- ESRRG downregulation in early spontaneous abortion induces mitochondrial damage, leading to impaired trophoblast function.Annals of medicine · 2026Article
- Pharmacology of estrogen-related receptors (ERRs) agonists.RSC chemical biology · 2026Review
- In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential.Rapid communications in mass spectrometry : RCM · 2026Article
- Exercise pills for cardiometabolic health cannot mimic the exercise milieu.Trends in endocrinology and metabolism: TEM · 2026Review
- Chemical optimization of the exercise mimetic SLU-PP-332 enables insight into estrogen-related receptor signaling.International journal of biological macromolecules · 2026Article
- Exercise-derived extracellular vesicles in oncology: a new frontier for translational nanomedicine.Journal of translational medicine · 2026Review
- Structural Pharmacology of Estrogen-Related Receptors.ACS pharmacology & translational science · 2026Review
- Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ.Molecular metabolism · 2026Article
- Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration and Mitigates Muscular Dystrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney disease.American journal of physiology. Renal physiology · 2025Review
- Which Approach to Choose to Counteract Musculoskeletal Aging? A Comprehensive Review on the Multiple Effects of Exercise.International journal of molecular sciences · 2025Review
- Molecular Mediators of the Cardiac Benefits of Exercise.Circulation research · 2025Review
- Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy.Journal of cachexia, sarcopenia and muscle · 2025Article
- Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study.Frontiers in physiology · 2025Article
- Uncovering a novel binding trench in ERRα: insights from molecular simulations.Frontiers in molecular biosciences · 2025Article
- The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.Molecular pharmacology · 2024Article
- Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training.Molecular metabolism · 2024Article
- Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal function.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 1 country.
Cyrielle BillonCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States.
Sadichha SitaulaCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States.
Subhashis BanerjeeDepartment of Pharmacology & Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
Ryan WelchGene Expression Laboratory Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Bahaa ElgendyCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States.ORCID 0000-0003-4800-7976
Lamees HegazyCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States.ORCID 0000-0003-2270-2284
Tae Gyu OhGene Expression Laboratory Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Melissa KazantzisThe Scripps Research Institute Jupiter, Jupiter, Florida 33458, United States.
Arindam ChatterjeeDepartment of Pharmacology & Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
John ChriviaDepartment of Pharmacology & Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
Matthew E HayesUniversity of Florida Genetics Institute, Gainesville, Florida 32610, United States.
Weiyi XuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, United States.
Angelica HamiltonDepartment of Molecular & Cellular Endocrinology, City of Hope, Duarte, California 91010, United States.
Janice M HussDepartment of Molecular & Cellular Endocrinology, City of Hope, Duarte, California 91010, United States.
Lilei ZhangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, United States.ORCID 0000-0001-6320-1318
John K WalkerDepartment of Pharmacology & Physiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, United States.
Michael DownesGene Expression Laboratory Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Ronald M EvansGene Expression Laboratory Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Thomas P BurrisCenter for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, Missouri 63110, United States.ORCID 0000-0003-2922-4449
University of Health Sciences and Pharmacy · USSaint Louis University · USSalk Institute for Biological Studies · USBaylor College of Medicine · USCity of Hope · USScripps Research Institute · USUniversity of Florida · US
Funding
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTranscriptional GenomicsP01HL088093 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WITZTUM, JOSEPH L. · 2008 to 2018
$26.4MHORMONAL REGULATION OF MAMMALIAN GENE EXPRESSIONR37DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2000 to 2019
$16.0MDevelopment of ROR ligands for treatment of circadian rhythm disordersR01MH092769 · NIMH · ST. LOUIS COLLEGE OF PHARMACY · PI BURRIS, THOMAS P, WALKER, JOHN K. · 2011 to 2020
$6.1MSpatial Regulation of Developmental Gene ExpressionR01HL105278 · NHLBI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2011 to 2019
$4.0MTargeting REV-ERB to treat Alzheimer's diseaseRF1AG060769 · NIA · UNIVERSITY OF FLORIDA · PI BURRIS, THOMAS P · 2019 to 2019
$3.7MREV-ERB ligands for treatment of anxiety disordersR01MH093429 · NIMH · SCRIPPS FLORIDA · PI BURRIS, THOMAS P · 2012 to 2016
$3.6MHormonal Regulation of Mammalian Gene ExpressionR01DK057978 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI EVANS, RONALD M · 2021 to 2024
$2.6MExercise Mimetics for Dementia and Alzheimer's DiseaseRF1AG077160 · NIA · UNIVERSITY OF FLORIDA · PI BURRIS, THOMAS P, ELGENDY, BAHAA · 2023 to 2023
$2.3MERRgamma Agonists to Treat Muscular DystrophyR01AR069280 · NIAMS · ST. LOUIS COLLEGE OF PHARMACY · PI BURRIS, THOMAS P, WALKER, JOHN K. · 2016 to 2018
$1.7MExercise Mimetics for Dementia and Alzheimer's DiseaseR01AG077160 · NIA · UNIVERSITY OF FLORIDA · PI Thomas P Burris, Bahaa Elgendy · 2026 to 2026
$727kNHLBI NIH HHS P01 HL088093NHLBI NIH HHS R01 HL105278NIAMS NIH HHS R01 AR069280NIA NIH HHS R01 AG077160NIA NIH HHS RF1 AG060769NIA NIH HHS RF1 AG077160NIDDK NIH HHS R01 DK057978NIDDK NIH HHS R37 DK057978NIEHS NIH HHS P42 ES010337NIMH NIH HHS R01 MH092769NIMH NIH HHS R01 MH093429
Abstract
Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors estrogen receptor-related receptors (ERRs) play an important role in skeletal muscle exercise capacity. Three ERR subtypes exist (ERRα, β, and γ), and although ERRβ/γ agonists have been designed, there have been significant difficulties in designing compounds with ERRα agonist activity. Additionally, there are limited synthetic agonists that can be used to target ERRs
Indexed as
EstrogensExercise ToleranceReceptors, EstrogenAnimalsERRalpha Estrogen-Related ReceptorMiceMuscle Fibers, SkeletalMuscle, SkeletalERRalpha Estrogen-Related ReceptorEsrrg protein, mouseEstrogensReceptors, Estrogen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.