Evidence map›Paper›PMID 36988877›Full record

ArticleAdvances in experimental medicine and biology2023

Biophysics of Membrane Stiffening by Cholesterol and Phosphatidylinositol 4,5-bisphosphate (PIP2).

Fathima T Doole, Sudipta Gupta, Teshani Kumarage, Rana Ashkar, Michael F Brown

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Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fathima T DooleDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA.
Sudipta GuptaDepartment of Physics and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, USA.
Teshani KumarageDepartment of Physics and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, USA.
Rana AshkarDepartment of Physics and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, USA. ashkar@vt.edu.
Michael F BrownDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ, USA. mfbrown@u.arizona.edu.
Virginia Tech · USUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell membranes regulate a wide range of phenomena that are implicated in key cellular functions. Cholesterol, a critical component of eukaryotic cell membranes, is responsible for cellular organization, membrane elasticity, and other critical physicochemical parameters. Besides cholesterol, other lipid components such as phosphatidylinositol 4,5-bisphosphate (PIP2) are found in minor concentrations in cell membranes yet can also play a major regulatory role in various cell functions. In this chapter, we describe how solid-state deuterium nuclear magnetic resonance (

Indexed as

Membrane LipidsPhosphatidylinositolsBiophysicsCell MembraneCholesterolLipid BilayersPhosphatidylinositol 4,5-DiphosphateCholesterolLipid BilayersMembrane LipidsPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsArea per lipidCholesterolMembrane elasticityMembrane viscosityNeutron spin-echoPIP2Polymer brush modelSolid-state 2H NMR

Identifiers

PMID36988877
OpenAlexW4361305154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.