Evidence map›Paper›PMID 36988746›Full record

ArticleJournal of neuro-oncology2023

Correlating volumetric and linear measurements of brain metastases on MRI scans using intelligent automation software: a preliminary study.

Burak B Ozkara, Christian Federau, Samir A Dagher, Debajani Pattnaik, F Eymen Ucisik, Melissa M Chen, Max Wintermark

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Article in Journal of neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Burak B OzkaraDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-8769-3342
Christian FederauFaculty of Medicine, University of Zurich, Pestalozzistrasse 3, Zurich, CH-8032, Switzerland.ORCID http://orcid.org/0000-0002-3803-6602
Samir A DagherDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0003-0155-7444
Debajani PattnaikDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.
F Eymen UcisikDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-6083-7465
Melissa M ChenDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-3274-2653
Max WintermarkDepartment of Neuroradiology, MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX, 77030, USA. max.wintermark@gmail.com.ORCID http://orcid.org/0000-0002-6726-3951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe Response Assessment in Neuro-Oncology Brain Metastases (RANO-BM) working group proposed a guide for treatment responses for BMs by utilizing the longest diameter; however, despite recognizing that many patients with BMs have sub-centimeter lesions, the group referred to these lesions as unmeasurable due to issues with repeatability and interpretation. In light of RANO-BM recommendations, we aimed to correlate linear and volumetric measurements in sub-centimeter BMs on contrast-enhanced MRI using intelligent automation software.

methodsIn this retrospective study, patients with BMs scanned with MRI between January 1, 2018, and December 31, 2021, were screened. Inclusion criteria were: (1) at least one sub-centimeter BM with an integer millimeter-longest diameter was noted in the MRI report; (2) patients were a minimum of 18 years of age; (3) patients with available pre-treatment three-dimensional T1-weighted spoiled gradient-echo MRI scan. The screening was terminated when there were 20 lesions in each group. Lesion volumes were measured with the help of intelligent automation software Jazz (AI Medical, Zollikon, Switzerland) by two readers. The Kruskal-Wallis test was used to compare volumetric differences.

resultsOur study included 180 patients. The agreement for volumetric measurements was excellent between the two readers. The volumes of the following groups were not significantly different: 1-2 mm, 1-3 mm, 1-4 mm, 2-3 mm, 2-4 mm, 3-4 mm, 3-5 mm, 4-5 mm, 5-6 mm, 5-7 mm, 6-7 mm, 6-8 mm, 6-9 mm, 7-8 mm, 7-9 mm, 8-9 mm.

conclusionOur findings indicate that the largest diameter of a lesion may not accurately represent its volume. Additional research is required to determine which method is superior for measuring radiologic response to therapy and which parameter correlates best with clinical improvement or deterioration.

Indexed as

Brain NeoplasmsMagnetic Resonance ImagingAutomationHumansRetrospective StudiesSoftwareBrain metastasesLinear measurementMagnetic resonance imagingRANOVolumetric measurement

Identifiers

PMID36988746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.