Evidence map›Paper›PMID 36988697›Full record

ArticleBasic research in cardiology2023

Membrane remodelling triggers maturation of excitation-contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes.

Fatemeh Kermani, Matias Mosqueira, Kyra Peters, Enrico D Lemma, Kleopatra Rapti, Dirk Grimm, Martin Bastmeyer, Magdalena Laugsch, Markus Hecker, Nina D Ullrich

Open access · hybridAbstract read
In one paragraph

Article in Basic research in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. DENND3-p.R534S disrupts dyadic microdomain architecture to drive potentially pro-arrhythmic calcium and electrophysiologic instability.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. An approach to evaluate the effect of inflammatory microvesicles on CaExperimental biology and medicine (Maywood, N.J.) · 2025
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Fatemeh KermaniDepartment of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Matias MosqueiraDepartment of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Kyra PetersDepartment of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Enrico D LemmaZoological Institute, Cell and Neurobiology, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Kleopatra RaptiDepartment of Infectious Diseases/Virology, Section Viral Vector Technologies, Heidelberg University, Heidelberg, Germany.
Dirk GrimmDepartment of Infectious Diseases/Virology, Section Viral Vector Technologies, Heidelberg University, Heidelberg, Germany.
Martin BastmeyerZoological Institute, Cell and Neurobiology, Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Magdalena LaugschInstitute of Human Genetics, Heidelberg University, Heidelberg, Germany.
Markus HeckerDepartment of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany.
Nina D UllrichDepartment of Cardiovascular Physiology, Heidelberg University, Heidelberg, Germany. nina.ullrich@physiologie.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-1077-3125
Heidelberg University · DEKarlsruhe Institute of Technology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medicine strongly depends on the electro-mechanical properties of these cells, especially regarding the Ca

Indexed as

Induced Pluripotent Stem CellsMyocytes, CardiacCalciumCalcium SignalingExcitation Contraction CouplingHumansRyanodine Receptor Calcium Release ChannelCalciumRyanodine Receptor Calcium Release Channel3D reshapingBIN1Excitation–contraction couplinghiPSC cardiomyocytesMaturationt-tubules

Identifiers

PMID36988697
PMCPMC10060306
OpenAlexW4361298505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.