Evidence map›Paper›PMID 36988692›Full record

ArticlePediatric nephrology (Berlin, Germany)2023

Real-life effects, complications, and outcomes in 39 critically ill neonates receiving continuous kidney replacement therapy.

Jinglin Xu, Lingyu Fang, Jiangbin Chen, Xinhua Chen, Hansong Yang, Weifeng Zhang, Lianqiang Wu, Dongmei Chen

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jinglin XuDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Lingyu FangDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Jiangbin ChenDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Xinhua ChenDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Hansong YangDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Weifeng ZhangDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Lianqiang WuDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China.
Dongmei ChenDepartment of Neonatology, Fujian Province, Quanzhou Maternity and Children's Hospital, Fengze Street, No 700, Quanzhou, 362000, China. chendm9090@163.com.
Maternity and Children's Hospital · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContinuous kidney replacement therapy (CKRT) has been expanded from simple kidney replacement therapy to the field of critical illness in children. However, CKRT is rarely used in critically ill neonates in the neonatal intensive care unit (NICU). This study aimed to describe patients' clinical characteristics at admission and CKRT initiation, CKRT effects, short-term outcomes, and predictors of death in critically ill neonates.

methodsA 7-year single-center retrospective study in a tertiary NICU.

resultsThirty-nine critically ill neonates received CKRT between May 2015 and April 2022 with a mortality rate of 35.9%. The most common primary diagnosis was neonatal sepsis in 15 cases (38.5%). Continuous veno-venous hemodiafiltration and continuous veno-venous hemofiltration were applied in 43.6% and 56.4% of neonates, respectively. The duration of CKRT was 44 (18, 72) h. Thirty-one patients (79.5%) had complications due to CKRT-related adverse events, and the most common complication was thrombocytopenia. Approximately 12 h after the CKRT initiation, urine volume, mean arterial pressure, and pH were increased, and serum creatinine, blood urea nitrogen, and blood lactate were decreased. In the multivariate logistic regression analysis, neonatal critical illness score [odds ratio 0.886 (0.786 ~ 0.998), P = 0.046] was an independent risk factor for death in critically ill neonates who received CKRT.

conclusionsCKRT can be an effective and feasible technique in critically ill neonates, but the overall mortality and CKRT-related complications are relatively high. Furthermore, the probability of death is greater among neonates with greater severity of illness at CKRT initiation. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyChildCritical IllnessHumansInfant, NewbornRenal Replacement TherapyRetrospective StudiesContinuous kidney replacement therapyHemodialysisHemofiltrationNeonate

Identifiers

PMID36988692
OpenAlexW4361294420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.