Evidence map›Paper›PMID 36988683›Full record

ArticleParasitology research2023

Toxoplasma gondii in CD36 -/- mice shows lethal infection and poor immunization with probable macrophage immune defects.

Andrea da Costa, Heitor Franco de Andrade

Abstract read
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In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrea da CostaProtozoology Laboratory, Instituto de Medicina Tropical de São Paulo and Department Pathology, School of Medicine, Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470, 1St Floor, São Paulo, SP, CEP 05403-000, Brazil.ORCID http://orcid.org/0000-0003-2273-4665
Heitor Franco de AndradeProtozoology Laboratory, Instituto de Medicina Tropical de São Paulo and Department Pathology, School of Medicine, Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 470, 1St Floor, São Paulo, SP, CEP 05403-000, Brazil. hfandrad@usp.br.ORCID http://orcid.org/0000-0003-4697-4647
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Experimental toxoplasmosis is an excellent model for adaptive immune response. Gamma-irradiated tachyzoites or soluble tachyzoite antigen extracts (STag) induce protection against experimental toxoplasmosis in mice. Scavenger receptors recognize irradiated proteins, promote their entry into cells, and lead to antigen presentation. CD36 is a specific scavenger receptor involved in intracellular transport of free fatty acid (FFA), cellular recycling, and intracellular trafficking in lipid rafts outside the lysosomal pathways. CD36 is also associated with an altered immune response, as CD36

Indexed as

Protozoan VaccinesToxoplasmaToxoplasmosisAnimalsAntibodies, ProtozoanAntigens, ProtozoanImmunizationImmunoglobulin GMacrophagesMiceMice, Inbred BALB CProtozoan ProteinsAntibodies, ProtozoanAntigens, ProtozoanImmunoglobulin GProtozoan ProteinsProtozoan VaccinesCD36Gamma radiationImmune responseKnockout miceMacrophageScavenger receptorSTagToxoplasma gondiiToxoplasmosis

Identifiers

PMID36988683
OpenAlexW4361291298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.