Evidence map›Paper›PMID 36988670›Full record

ArticleBasic research in cardiology2023

Oxygen-sensing pathways below autoregulatory threshold act to sustain myocardial oxygen delivery during reductions in perfusion pressure.

Cooper M Warne, Salman I Essajee, Selina M Tucker, C Alberto Figueroa, Daniel A Beard, Gregory M Dick, Johnathan D Tune

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Unraveling the Gordian knot of coronary pressure-flow autoregulation.Journal of molecular and cellular cardiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Cooper M WarneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., TX, 76107, Fort Worth, USA.
Salman I EssajeeDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., TX, 76107, Fort Worth, USA.
Selina M TuckerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., TX, 76107, Fort Worth, USA.
C Alberto FigueroaSection of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA.
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, USA.
Gregory M DickDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., TX, 76107, Fort Worth, USA.
Johnathan D TuneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., TX, 76107, Fort Worth, USA. johnathan.tune@unthsc.edu.
University of North Texas · USUniversity of Michigan–Ann Arbor · USUniversity of North Texas Health Science Center · US

Funding

Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale ModelingR01HL158723 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A, FIGUEROA, CARLOS ALBERTO · 2022 to 2025
$2.7M
NHLBI NIH HHS R01 HL158723
6 · The paper itself

Abstract

The coronary circulation has an innate ability to maintain constant blood flow over a wide range of perfusion pressures. However, the mechanisms responsible for coronary autoregulation remain a fundamental and highly contested question. This study interrogated the local metabolic hypothesis of autoregulation by testing the hypothesis that hypoxemia-induced exaggeration of the metabolic error signal improves the autoregulatory response. Experiments were performed on open-chest anesthetized swine during stepwise changes in coronary perfusion pressure (CPP) from 140 to 40 mmHg under normoxic (n = 15) and hypoxemic (n = 8) conditions, in the absence and presence of dobutamine-induced increases in myocardial oxygen consumption (MVO

Indexed as

DobutamineOxygenAnimalsBlood PressureCoronary CirculationHomeostasisHypoxiaMyocardiumOxygen ConsumptionPerfusionSwineDobutamineOxygenCoronary circulationFeedbackHomeostasisHypoxiaOxygen consumption

Identifiers

PMID36988670
PMCPMC10797605
OpenAlexW4361302007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.