Evidence map›Paper›PMID 36988482›Full record

ArticleNursing research

Lipidomics, Acute Ischemic Stroke, Symptoms, and Outcomes: Observational Study Protocol.

Sarah R Martha, Alice Y Pen, Laura Stone McGuire, Ali Alaraj, Mark Maienschein-Cline, Sanjib Basu, Jeffrey A Loeb, Hilaire J Thompson

Open access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

U.S. National Science Foundation · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Omics and Symptom Science Training ProgramT32NR016913 · NINR · UNIVERSITY OF WASHINGTON · PI CYNTHIA M DOUGHERTY, Margaret McLean Heitkemper · 2017 to 2026
$3.2M
Lipidomics in Acute Ischemic Stroke: Relationship to Symptoms and OutcomesK23NR019864 · NINR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MARTHA, SARAH R · 2021 to 2023
$528k
NCATS NIH HHS UL1 TR002003NINR NIH HHS K23 NR019864NINR NIH HHS T32 NR016913
6 · The paper itself

Abstract

backgroundAcute ischemic stroke is one of the leading causes of death and disability globally. Recent advances in omics methodology enable lipidomic profiling, which may provide knowledge of the underlying pathology of acute ischemic stroke and its associated outcomes.

objectiveThis study aims to examine the longer-term relationships between symptoms and outcomes following acute ischemic stroke and the underlying lipidomic signatures over 6 months during recovery between acute ischemic stroke patients who received reperfusion therapies and those who did not.

methodsThis prospective cohort study will enroll 104 participants post-acute ischemic stroke in two groups based on their receipt of reperfusion therapy (Group 1) or not (Group 2; n = 52/group). Peripheral plasma samples will be collected from both groups for lipidomic analysis over 6 months. Arterial blood samples will be collected during the procedure for those receiving reperfusion. Self-reported symptoms and outcome data will be collected from both groups. DISCUSSION: We will compare and examine the associations among plasma lipidomic biomarkers and symptoms and cognitive, functional, and health-related quality of life outcomes over 6 months between acute ischemic stroke patients who did and did not receive reperfusion intervention.

Indexed as

Brain IschemiaIschemic StrokeStrokeHumansLipidomicsObservational Studies as TopicProspective StudiesQuality of LifeTreatment Outcome

Identifiers

PMID36988482
PMCPMC10293104
OpenAlexW4361200027

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.