Evidence map›Paper›PMID 36988421›Full record

ArticleThe Journal of organic chemistry2023

A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes.

Lucia De Rosa, Ivan Hawala, Rossella Di Stasi, Rachele Stefania, Martina Capozza, Donatella Nava, Luca Domenico D'Andrea

Open access · hybridAbstract read
In one paragraph

Article in The Journal of organic chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Lucia De RosaIstituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy.
Ivan HawalaCentro di Imaging Molecolare, Dipartimento di Biotecnologie Molecolari e Scienze per La Salute, Università di Torino, via Nizza 52, 10126 Torino, Italy.ORCID 0000-0003-1619-739X
Rossella Di StasiIstituto di Biostrutture e Bioimmagini, Consiglio Nazionale Delle Ricerche, Via Pietro Castellino 111, 80131 Napoli, Italy.
Rachele StefaniaCentro di Imaging Molecolare, Dipartimento di Biotecnologie Molecolari e Scienze per La Salute, Università di Torino, via Nizza 52, 10126 Torino, Italy.
Martina CapozzaCentro di Imaging Molecolare, Dipartimento di Biotecnologie Molecolari e Scienze per La Salute, Università di Torino, via Nizza 52, 10126 Torino, Italy.
Donatella NavaDipartimento di Scienze Farmaceutiche, Università di Milano, Via Venezian 21, 20133 Milano, Italy.
Luca Domenico D'AndreaIstituto di Scienze e Tecnologie Chimiche "G. Natta", Consiglio Nazionale Delle Ricerche, Via M. Bianco 9, 20131 Milano, Italy.ORCID 0000-0002-2589-216X
University of Turin · ITInstitute of Biostructure and Bioimaging · ITIstituto di Chimica Biomolecolare · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.

Indexed as

PeptidesSulfhydryl CompoundsMaleimidesMaleimidesPeptidesSulfhydryl Compoundsthiol-maleimide

Identifiers

PMID36988421
PMCPMC10088022
OpenAlexW4361283536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.