ArticleHuman brain mapping2023
General dimensions of human brain morphometry inferred from genome-wide association data.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- The causal relationship between neuroimaging and Parkinson's disease: A two-sample Mendelian randomization study.Medicine · 2026Article
- Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization.Neurotoxicity research · 2026Article
- The Impact of Brain Morphometry on Low Back Pain Risk: A Mendelian Randomization Study.Journal of pain research · 2026Article
- Causal relationships between neuroimaging phenotypes and the risk of early and late-onset alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Genetic associations with educational fields.Nature genetics · 2025Article
- Distinguishing specific from broad genetic associations between external correlates and common factors.Bioinformatics (Oxford, England) · 2025Article
- Symptoms of problematic alcohol use differ in their genetic associations with comorbid internalizing, externalizing, and neurodevelopmental psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling.Nature genetics · 2025Article
- Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI.Nature communications · 2025Article
- Distinguishing Specific from Broad Genetic Associations between External Correlates and Common Factors.bioRxiv : the preprint server for biology · 2025Article
- Genetically Proxied Phosphodiesterase Type 5 (PDE5) Inhibition and Risk of Dementia: A Drug Target Mendelian Randomization Study.Molecular neurobiology · 2025Article
- The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study.Scientific reports · 2025Article
- Mapping fatigue: discovering brain regions and genes linked to fatigue susceptibility.Journal of translational medicine · 2025Article
- Structural MRI of brain similarity networks.Nature reviews. Neuroscience · 2025Review
- Joint modeling of human cortical structure: Genetic correlation network and composite-trait genetic correlation.NeuroImage · 2024Article
- No genetic causal associations between periodontitis and brain atrophy or cognitive impairment: evidence from a comprehensive bidirectional Mendelian randomization study.BMC oral health · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Understanding the neurodegenerative mechanisms underlying cognitive decline in the general population may facilitate early detection of adverse health outcomes in late life. This study investigates genetic links between brain morphometry, ageing and cognitive ability. We develop Genomic Principal Components Analysis (Genomic PCA) to model general dimensions of brain-wide morphometry at the level of their underlying genetic architecture. Genomic PCA is applied to genome-wide association data for 83 brain-wide volumes (36,778 UK Biobank participants) and we extract genomic principal components (PCs) to capture global dimensions of genetic covariance across brain regions (unlike ancestral PCs that index genetic similarity between participants). Using linkage disequilibrium score regression, we estimate genetic overlap between those general brain dimensions and cognitive ageing. The first genetic PCs underlying the morphometric organisation of 83 brain-wide regions accounted for substantial genetic variance (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.