Evidence map›Paper›PMID 36987923›Full record

ArticleHypertension (Dallas, Tex. : 1979)2023

Associations of Urine Biomarkers of Kidney Tubule Health With Incident Hypertension and Longitudinal Blood Pressure Change in Middle-Aged Adults: The CARDIA Study.

Muhammad B Khan, Rebecca Scherzer, Cora E Lewis, Rakesh Malhotra, Joachim H Ix, Michael G Shlipak, Orlando M Gutiérrez

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Muhammad B KhanDepartments of Medicine (M.B.K., O.M.G.), University of Alabama at Birmingham.
Rebecca ScherzerKidney Health Research Collaborative, San Francisco Veterans Affairs Health Care System (R.S., M.G.S.), University of California.ORCID 0000-0002-1579-5390
Cora E LewisEpidemiology (C.E.L., O.M.G.), University of Alabama at Birmingham.ORCID 0000-0002-2301-5796
Rakesh MalhotraDivision of Nephrology-Hypertension (R.M., J.H.I.), University of California.
Joachim H IxDivision of Nephrology-Hypertension (R.M., J.H.I.), University of California.
Michael G ShlipakKidney Health Research Collaborative, San Francisco Veterans Affairs Health Care System (R.S., M.G.S.), University of California.ORCID 0000-0002-9559-204X
Orlando M GutiérrezDepartments of Medicine (M.B.K., O.M.G.), University of Alabama at Birmingham.ORCID 0000-0001-6593-3571
University of Alabama at Birmingham · USSan Francisco VA Health Care System · USVA San Diego Healthcare System · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MEHTA, RAVINDRA L. · 2008 to 2022
$18.3M
TRAINING IN CELLULAR PHYSIOLOGY MEMBRANE TRANSPORTT32DK007545 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 1987 to 2023
$4.5M
Non Invasive Assessment of Microcirculation Function and Kidney DiseaseK23DK132680 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rakesh Malhotra · 2022 to 2026
$971k
Mentored patient-oriented research in disparities in cardiovascular and kidney diseaseK24DK116180 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M · 2018 to 2022
$749k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INIDDK NIH HHS K23 DK132680NIDDK NIH HHS K24 DK116180NIDDK NIH HHS P30 DK079337NIDDK NIH HHS T32 DK007545
6 · The paper itself

Abstract

backgroundUrine biomarkers of kidney tubule injury associate with incident hypertension in older adults with comorbidities, but less is known about these associations in younger adults.

methodsIn 1170 participants of the CARDIA study (Coronary Artery Risk Development in Young Adults; mean age, 45 years; 40% Black people; 56% women) without hypertension, cardiovascular disease, or kidney disease at baseline, we examined associations of urine MCP-1 (monocyte chemoattractant protein-1), α1m (alpha-1-microglobulin), KIM-1 (kidney injury molecule-1), EGF (epidermal growth factor), IL (interleukin)-18, YKL-40 (chitinase-3-like protein 1), and UMOD (uromodulin) with incident hypertension (onset of systolic blood pressure [BP] ≥130 mm Hg or diastolic BP ≥80 mm Hg or initiation of hypertension medications) and longitudinal BP change in models adjusted for hypertension risk factors, estimated glomerular filtration rate, and albuminuria.

resultsAfter a median 9.9 (interquartile range, 5.9-10.2) years, 376 participants developed incident hypertension. In demographic-adjusted analyses, higher tertiles of EGF associated with lower risk of incident hypertension in both Black and White participants. After multivariable adjustment, the risk of incident hypertension remained lower in tertile 2 (hazard ratio, 0.70 [95% CI, 0.50-0.97]) and tertile 3 (hazard ratio, 0.58 [0.39-0.85]) of EGF versus tertile 1. In fully adjusted models, participants in EGF tertile 3 had smaller 10-year increases in systolic (-3.4 [95% CI, -6.1 to -0.7] mm Hg) and diastolic BP (-2.6 [95% CI, -4.6 to -0.6] mm Hg) than tertile 1. Other biomarkers showed inconsistent associations with incident hypertension and BP change.

conclusionsIn middle-aged adults without hypertension, cardiovascular disease, or kidney disease, higher urine EGF associated with lower risk of incident hypertension and lower 10-year BP elevations.

Indexed as

Cardiovascular DiseasesHypertensionHypotensionKidney DiseasesAgedBiomarkersBlood PressureEpidermal Growth FactorFemaleGlomerular Filtration RateHumansKidney TubulesMaleMiddle AgedRisk FactorsYoung AdultBiomarkersEpidermal Growth Factorbiomarkersblood pressurecardiovascular diseaseshypertensionkidney diseases

Identifiers

PMID36987923
PMCPMC10192098
OpenAlexW4361292036

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.