Evidence map›Paper›PMID 36987520›Full record

ArticleiScience2023

A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease.

Alexandra Alvergne, Gabriella Kountourides, M Austin Argentieri, Lisa Agyen, Natalie Rogers, Dawn Knight, Gemma C Sharp, Jacqueline A Maybin, Zuzanna Olszewska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Alexandra AlvergneISEM, Montpellier University, CNRS, IRD, Montpellier, France.
Gabriella KountouridesSchool of Anthropology and Museum Ethnography, Oxford, UK.
M Austin ArgentieriSchool of Anthropology and Museum Ethnography, Oxford, UK.
Lisa AgyenLong COVID Support, England and Wales.
Natalie RogersLong COVID Support, England and Wales.
Dawn KnightLong COVID Support, England and Wales.
Gemma C SharpMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Jacqueline A MaybinMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Zuzanna OlszewskaSchool of Anthropology and Museum Ethnography, Oxford, UK.
Centre National de la Recherche Scientifique · FRMassachusetts General Hospital · USMRC Centre for Reproductive Health · GBUniversity of Exeter · GB

Funding

Medical Research Council G1002033Medical Research Council MR/N022556/1Wellcome Trust 209589/Z/17/Z
6 · The paper itself

Abstract

There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. Our objectives were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease. We performed a secondary analysis of a retrospective online survey conducted in the UK in March 2021. In pre-menopausal vaccinated participants (n = 4,989), 18% reported menstrual cycle changes after their first COVID-19 vaccine injection. The prevalence of reporting any menstrual changes was higher for women who smoke, have a history of COVID-19 disease, or are not using estradiol-containing contraceptives. In a second sample including both vaccinated and unvaccinated participants (n = 12,579), COVID-19 vaccination alone was not associated with abnormal menstrual cycle parameters, while a history of COVID-19 disease was associated with an increased risk of reporting heavier bleeding, "missed" periods, and inter-menstrual bleeding.

Indexed as

Health sciencesImmunologyPublic healthWomen's health

Identifiers

PMID36987520
PMCPMC10015085
OpenAlexW4324340216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.