Evidence map›Paper›PMID 36987406›Full record

ArticleInternational journal of general medicine2023

Peripheral Mononuclear Cells Surface Markers Evaluation in Different Stages of Hepatocellular Carcinoma; in a Trial for Early and Accurate Diagnosis in Patients with Post-Hepatitis Liver Cirrhosis and Unremarkable Raised AFP.

Heba Ahmed Osman, Hanaa Nafady-Hego, Khalid Ali Nasif, Heba A Ahmed, Ekram Abdel-Rahman Mahmoud, Noher Mohamad Abass, Amal Rayan, Marwa Ahmed Mahmoud, Asmaa Nafady

Open access · goldAbstract read
In one paragraph

Article in International journal of general medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Heba Ahmed OsmanDepartment of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.ORCID 0000-0001-6302-3443
Hanaa Nafady-HegoDepartment of Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0002-5562-0245
Khalid Ali NasifDepartment of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.
Heba A AhmedDepartment of Clinical and Chemical Pathology Sohag Faculty of Medicine Sohag University, Sohag, Egypt.ORCID 0000-0002-3693-0563
Ekram Abdel-Rahman MahmoudDepartment of Medical Microbiology & Immunology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Noher Mohamad AbassDepartment of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt.
Amal RayanDepartment of Clinical Oncology, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0001-5995-9177
Marwa Ahmed MahmoudDepartment of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Asmaa NafadyDepartment of Clinical and Chemical Pathology, Qena Faculty of Medicine, South Valley University, Qena, Egypt.
Sohag University · EGAssiut University · EGSouth Valley University · EGKing Khalid University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: HCC is frequently diagnosed late, when only palliative treatment is available. So, we try to use different immunological markers to identify early HCC in patients with unremarkable raised AFP. Methods: This study was conducted on 112 participants divided into two equal groups: Group I, 56 patients with liver cirrhosis and different stages of HCC; Group II, 56 patients with liver cirrhosis. The diagnosis of HCC was based on AASLD guidelines. TNM and BCLC classification systems are used for staging of HCC. Results: A significant reduction in the median percentage of lymphocyte subset (CD3 Conclusion: Patients with HCC with unremarkable raised AFP showed marked reduction in lymphocytes, natural killer cells, and all monocyte subpopulations. In addition, patients with advanced HCC showed increased CD33

Indexed as

Barcelona clinic liver cancerhepatocellular carcinomalymphocyte subsetmetastases (M)monocyte subpopulationnodes (N)tumor (T)

Identifiers

PMID36987406
PMCPMC10040161
OpenAlexW4353076837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.