Evidence map›Paper›PMID 36987269›Full record

ReviewPolymers2023

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy.

Pedro D Fernandes, Fernão D Magalhães, Rúben F Pereira, Artur M Pinto

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pedro D FernandesLEPABE, Faculdade de Engenharia, Universidade do Porto, Rua Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0001-9381-4916
Fernão D MagalhãesLEPABE, Faculdade de Engenharia, Universidade do Porto, Rua Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0002-4447-4473
Rúben F Pereirai3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.ORCID 0000-0002-7255-3400
Artur M PintoLEPABE, Faculdade de Engenharia, Universidade do Porto, Rua Roberto Frias, 4200-465 Porto, Portugal.ORCID 0000-0001-8184-8254
Universidade do Porto · PT

Funding

ALiCE LA/P/0045/2020CQVR UIDB/QUI/00616/2020FCT/MCTES (PIDDAC) - FCT R&D Project: PhotoRect 2022.04494.PTDCFCT/MCTES (PIDDAC)- UT Austin PT Program UTAP-EXPL/NPN/0044/2021Foundation for Science and Technology (FCT)-Scientific Employment Stimulus-Individual Call CEECIND/03908/2017Institute for Research and Innovation in Health-i3S. UIDB/04293/2020LEPABE UIDB/00511/2020LEPABE UIDP/00511/2020Norte Portugal Regional Operational Programme (NORTE 2020) NORTE-01-0145-FEDER-000054
6 · The paper itself

Abstract

Conventional cancer therapies, such as radiotherapy and chemotherapy, can have long-term side effects. Phototherapy has significant potential as a non-invasive alternative treatment with excellent selectivity. Nevertheless, its applicability is restricted by the availability of effective photosensitizers and photothermal agents, and its low efficacy when it comes to avoiding metastasis and tumor recurrence. Immunotherapy can promote systemic antitumoral immune responses, acting against metastasis and recurrence; however, it lacks the selectivity displayed by phototherapy, sometimes leading to adverse immune events. The use of metal-organic frameworks (MOFs) in the biomedical field has grown significantly in recent years. Due to their distinct properties, including their porous structure, large surface area, and inherent photo-responsive properties, MOFs can be particularly useful in the fields of cancer phototherapy and immunotherapy. MOF nanoplatforms have successfully demonstrated their ability to address several drawbacks associated with cancer phototherapy and immunotherapy, enabling an effective and low-side-effect combinatorial synergistical treatment for cancer. In the coming years, new advancements in MOFs, particularly regarding the development of highly stable multi-function MOF nanocomposites, may revolutionize the field of oncology.

Indexed as

cancer therapyimmunotherapynanomaterialsphotodynamic therapyphotothermal therapy

Identifiers

PMID36987269
PMCPMC10053741
OpenAlexW4327736832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.