Evidence map›Paper›PMID 36987212›Full record

ArticlePolymers2023

Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans.

Fernanda Petzold Pauli, Cyntia Silva Freitas, Patricia Ribeiro Pereira, Alviclér Magalhães, Fernando de Carvalho da Silva, Vania M F Paschoalin, Vitor Francisco Ferreira

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fernanda Petzold PauliDepartamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói 24241-000, Brazil.
Cyntia Silva FreitasDepartamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
Patricia Ribeiro PereiraDepartamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.ORCID 0000-0002-9008-9904
Alviclér MagalhãesDepartamento de Química Orgânica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.
Fernando de Carvalho da SilvaDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Fluminense, Niterói 24020-141, Brazil.ORCID 0000-0002-2042-3778
Vania M F PaschoalinDepartamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-909, Brazil.ORCID 0000-0001-6093-134X
Vitor Francisco FerreiraDepartamento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, Niterói 24241-000, Brazil.ORCID 0000-0002-2166-766X
Universidade Federal do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superio/Fundação para a Ciência e a Tecnologia 99999.008550/2014-00Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.448/2014, E-26/E-26/111.227/2014, 210.394/2014, E-26/010.002007/2014, E-26/203.204/2015, E-26/010.000.984/2019, E-26/010.001.485/2019, E-26/202.815/2018, E-26/201.016/2022, E-26/204.372/2021National Council for Scientific and Technological Development 310591/2014-7, 312158/2017-3
6 · The paper itself

Abstract

Biopolymers obtained from natural macromolecules are noteworthy among materials presenting high biocompatibility and adequate biodegradability, as is the case of chitosan (CS), making this biopolymeric compound a suitable drug delivery system. Herein, chemically-modified CS were synthetized using 2,3-dichloro-1,4-naphthoquinone (1,4-NQ) and the sodium salt of 1,2-naphthoquinone-4-sulfonic acid (1,2-NQ), producing 1,4-NQ-CS and 1,2-NQ-CS by three different methods, employing an ethanol and water mixture (EtOH:H

Indexed as

antibacterial and anti-human mammary adenocarcinoma effectschemotherapeutic adjuvantdrug deliveryin vitro toxicity evaluationpreclinical testsRAMANssNMR

Identifiers

PMID36987212
PMCPMC10053705
OpenAlexW4324144050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.