Evidence map›Paper›PMID 36987136›Full record

ArticlePolymers2023

Development and Characterization of Drug Loaded PVA/PCL Fibres for Wound Dressing Applications.

Ali Afzal, Mohammed Jalalah, Abid Noor, Zubair Khaliq, Muhammad Bilal Qadir, Rashid Masood, Ahsan Nazir, Sheraz Ahmad, Faheem Ahmad, Muhammad Irfan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Ali AfzalDepartment of Textile Engineering, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0001-8516-7472
Mohammed JalalahPromising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.ORCID 0000-0002-6828-3874
Abid NoorDepartment of Textile Technology, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0001-7795-1128
Zubair KhaliqDepartment of Materials, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0002-8278-232X
Muhammad Bilal QadirDepartment of Textile Engineering, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0003-4571-5328
Rashid MasoodDepartment of Textile Technology, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.
Ahsan NazirDepartment of Textile Engineering, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0002-5141-3767
Sheraz AhmadDepartment of Textile Technology, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.ORCID 0000-0001-6231-6578
Faheem AhmadDepartment of Textile Technology, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.
Muhammad IrfanDepartment of Textile Engineering, School of Engineering & Technology, National Textile University, Faisalabad 37610, Pakistan.
Munazza AfzalInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan.
Mohd FaisalPromising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.
Saeed A AlsareiiPromising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.ORCID 0000-0003-3579-1386
Farid A HarrazPromising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.ORCID 0000-0001-7776-7099
National Textile University · PKNajran University · SAUniversity of Veterinary and Animal Sciences · PK

Funding

Higher Education Commission 9473/Punjab/NRPU/R&D/HEC/2017Najran University NU/RC/SERC/11/6
6 · The paper itself

Abstract

Nowadays, synthetic polymers are used in medical applications due to their special biodegradable, biocompatible, hydrophilic, and non-toxic properties. The materials, which can be used for wound dressing fabrication with controlled drug release profile, are the need of the time. The main aim of this study was to develop and characterize polyvinyl alcohol/polycaprolactone (PVA/PCL) fibres containing a model drug. A dope solution comprising PVA/PCL with the drug was extruded into a coagulation bath and became solidified. The developed PVA/PCL fibres were then rinsed and dried. These fibres were tested for Fourier transform infrared spectroscopy, linear density, topographic analysis, tensile properties, liquid absorption, swelling behaviour, degradation, antimicrobial activity, and drug release profile for improved and better healing of the wound. From the results, it was concluded that PVA/PCL fibres containing a model drug can be produced by using the wet spinning technique and have respectable tensile properties; adequate liquid absorption, swelling %, and degradation %; and good antimicrobial activity with the controlled drug release profile of the model drug for wound dressing applications.

Indexed as

antimicrobialdrug releasemedicalpolycaprolactonewound dressing

Identifiers

PMID36987136
PMCPMC10057071
OpenAlexW4323667792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.